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Literature summary for 1.1.1.37 extracted from

  • Chapman, A.D.M.; Cortes, A.; Dafforn, T.R.; Clarke, A.R.; Brady, R.L.
    Structural basis of substrate specificity in malate dehydrogenases: Crystal structure of a ternary complex of porcine cytoplasmic malate dehydrogenase, alpha-ketomalonate and tetrahydoNAD (1999), J. Mol. Biol., 285, 703-712.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
cMDH cloned and overexpressed in Escherichia coli Sus scrofa

Crystallization (Commentary)

Crystallization (Comment) Organism
recombinant porcine cMDH Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Sus scrofa 5737
-
cytosol
-
Thermus thermophilus 5829
-
cytosol
-
Sus scrofa 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
malate + NAD+ Thermus thermophilus
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Escherichia coli
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Sus scrofa
-
oxaloacetate + NADH + H+
-
r

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Sus scrofa
-
pig
-
Thermus thermophilus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NAD+
-
Thermus thermophilus oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Escherichia coli oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Sus scrofa oxaloacetate + NADH + H+
-
r
1,4,5,6-tetrahydronicotinamide + L-malate
-
Sus scrofa ?
-
?
alpha-keto-malonate + NADH
-
Sus scrofa ? + NAD+
-
?
L-lactate + NAD+ cMDH less catalytically efficient than against its natural substrate malate Sus scrofa ? + NADH
-
?
malate + NAD+
-
Thermus thermophilus oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Escherichia coli oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Sus scrofa oxaloacetate + NADH + H+
-
r
oxaloacetate + NADH
-
Thermus thermophilus L-malate + NAD+
-
r
oxaloacetate + NADH
-
Escherichia coli L-malate + NAD+
-
r
oxaloacetate + NADH
-
Sus scrofa L-malate + NAD+
-
r
pyruvate + NAD+ cMDH less catalytically efficient than against its natural substrate malate Sus scrofa ? + NADH
-
?