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Literature summary for 1.1.1.363 extracted from

  • White, B.J.; Levy, H.R.
    Modification of glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides with the 2',3'-dialdehyde derivative of NADP+ (oNADP+) (1987), J. Biol. Chem., 262, 1223-1229.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
NADP+ 2',3'-dialdehyde irreversible inactivation in absence of substrate. The inactivation is first order with respect to NADP+ concentration and follows saturation kinetics, indicating that the enzyme initially forms a reversible complex with the inhibitor followed by covalent modification. NADP+ and NAD+ protect the enzyme from inactivation. One molecule of NADP+ 2',3'-dialdehyde binds per subunit of glucose-6-phosphate dehydrogenase when the enzyme is completely inactivated Leuconostoc mesenteroides

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
200
-
NADP+ 2',3'-dialdehyde 25°C, pH 7.8 Leuconostoc mesenteroides

Organism

Organism UniProt Comment Textmining
Leuconostoc mesenteroides
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 6-phosphate + NADP+ 2',3'-dialdehyde
-
Leuconostoc mesenteroides 6-phospho-D-glucono-1,5-lactone + NADPH 2',3'-dialdehyde + H+
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.8
-
NADP+ 2',3'-dialdehyde 25°C, pH 7.8 Leuconostoc mesenteroides