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Literature summary for 1.1.1.363 extracted from

  • Coe, E.L.; Hsu, L.H.
    Acyl coenzyme A inhibition of Leuconostoc mesenteroides glucose-6-phosphate dehydrogenase: a comparison of the TPN and DPN linked reactions (1973), Biochem. Biophys. Res. Commun., 53, 66-69.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
acetyl-CoA 2.6 mM, no inhibition of NADP+-dependent reaction, 70% inhibition of NAD+-dependent reaction Leuconostoc mesenteroides
ATP 3.9 mM, 50% inhibition of NADP+-dependent reaction, 90% inhibition of NAD+-dependent reaction Leuconostoc mesenteroides
cis-9-octadecenoyl-CoA 2.0 mM, 9% inhibition of NADP+-dependent reaction, 90% inhibition of NAD+-dependent reaction Leuconostoc mesenteroides
CoA 3.4 mM, 12% inhibition of NADP+-dependent reaction, 82% inhibition of NAD+-dependent reaction Leuconostoc mesenteroides
malonyl-CoA 2.4 mM, no inhibition of NADP+-dependent reaction, 14% inhibition of NAD+-dependent reaction Leuconostoc mesenteroides

Organism

Organism UniProt Comment Textmining
Leuconostoc mesenteroides
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 6-phosphate + NAD+
-
Leuconostoc mesenteroides 6-phospho-D-glucono-1,5-lactone + NADH + H+
-
?
D-glucose 6-phosphate + NADP+
-
Leuconostoc mesenteroides 6-phospho-D-glucono-1,5-lactone + NADPH + H+
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Leuconostoc mesenteroides
NADP+
-
Leuconostoc mesenteroides

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.15
-
cis-9-octadecenoyl-CoA 24°C, pH 7.8, inhibition of NAD+-dependent reaction Leuconostoc mesenteroides
0.4
-
malonyl-CoA 24°C, pH 7.8, inhibition of NAD+-dependent reaction Leuconostoc mesenteroides
0.5
-
ATP 24°C, pH 7.8, inhibition of NAD+-dependent reaction Leuconostoc mesenteroides
0.7
-
CoA 24°C, pH 7.8, inhibition of NAD+-dependent reaction Leuconostoc mesenteroides
1
-
acetyl-CoA 24°C, pH 7.8, inhibition of NAD+-dependent reaction Leuconostoc mesenteroides