Cloned (Comment) | Organism |
---|---|
gene hadh, quantitative real-time PCR expression analysis | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of hadh knockout mice by insertion of gene-trap vector pGT0Lxf in the ES cell line E14Tg2a.4, deletion of hadh results in a defective enzymatic activity of SCHAD, phenotype, overview. Deletion of hadh reduces body weight and adipose tissue depots, and leads to impaire thermogenesis | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-3-hydroxyacyl-CoA + NAD+ | Mus musculus | - |
3-oxoacyl-CoA + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
gene hadh | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-3-hydroxyacyl-CoA + NAD+ | - |
Mus musculus | 3-oxoacyl-CoA + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
medium- and short-chain-3-hydroxyacyl-CoA dehydrogenase | - |
Mus musculus |
medium- and short-chain-3-hydroxyacyl-coenzyme A dehydrogenase | - |
Mus musculus |
SCHAD | - |
Mus musculus |
short-chain L-3-hydroxyacyl-CoA dehydrogenase | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | mice lacking SCHAD, hadh-/-, display a lower body weight and a reduced fat mass in comparison with hadh+/+ mice under high-fat diet conditions, presumably due to an impaired fuel efficiency, the loss of acylcarnitines via the urine, and increased body temperature. Food intake, total energy expenditure, and locomotor activity are not altered in knockout mice | Mus musculus |
metabolism | the enzyme catalyzes the third reaction of the mitochondrial beta-oxidation cascade, the oxidation of 3-hydroxyacyl-CoA to 3-ketoacyl-CoA, for medium-andshort-chain fatty acids | Mus musculus |
physiological function | the enzyme is involved in thermogenesis, in the maintenance of body weight, and in the regulation of nutrient-stimulated insulin secretion. It plays an important role in adaptive thermogenesis | Mus musculus |