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Literature summary for 1.1.1.35 extracted from

  • El-Fakhri, M.; Middleton, B.
    The existence of an inner-membrane-bound, long acyl-chain-specific 3-hydroxyacyl-CoA dehydrogenase in mammalian mitochondria (1982), Biochim. Biophys. Acta, 713, 270-279.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
70000
-
gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-3-hydroxybutyryl-CoA + NAD+ Rattus norvegicus
-
acetoacetyl-CoA + NADH
-
r

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
heart
-
Rattus norvegicus
-
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.033
-
enzyme activity in brain mitochondria, substrate acetoacetyl-CoA Rattus norvegicus
0.48
-
enzyme activity in inner membrane of liver mitochondria, substrate acetoacetyl-CoA Rattus norvegicus
0.78
-
enzyme activity in kidney mitochondria, substrate acetoacetyl-CoA Rattus norvegicus
1.5
-
enzyme activity in heart mitochondria, substrate acetoacetyl-CoA Rattus norvegicus
1.67
-
enzyme activity in liver mitochondria, substrate acetoacetyl-CoA Rattus norvegicus
2.3
-
enzyme activity in liver mitoplasts, substrate acetoacetyl-CoA Rattus norvegicus
3.4
-
enzyme activity in matrix of liver mitochondria, substrate acetoacetyl-CoA Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-3-hydroxybutyryl-CoA + NAD+
-
Rattus norvegicus acetoacetyl-CoA + NADH
-
r
(S)-3-hydroxybutyryl-CoA + NAD+ highest activity with acetoacetyl-CoA, significant activity with increasing chain length up to C16 Rattus norvegicus acetoacetyl-CoA + NADH
-
r

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Rattus norvegicus