Protein Variants | Comment | Organism |
---|---|---|
F22Y | the mutation causes a 2.5fold decrease in Km for 2,5-didehydro-D-gluconate whereas the value of kcat remains essentially unchanged | Corynebacterium sp. |
Q192R | the mutation primarily affects the kcat parameter toward the 2,5-didehydro-D-gluconate substrate, increasing its value approximately 2.5fold, whereas Km is relatively unaffected, or increases slightly | Corynebacterium sp. |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Corynebacterium sp. | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,5-didehydro-D-gluconate + NADPH + H+ | isoform DKGR B exhibits 66fold higher specific activity toward 2,5-didehydro-D-gluconate than isoform DKGR A | Corynebacterium sp. | 2-dehydro-L-gulonate + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
2,5-diketo-D-gluconate reductase | - |
Corynebacterium sp. |
2,5-DKGR A | isoform | Corynebacterium sp. |
2,5-DKGR B | isoform | Corynebacterium sp. |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | dependent on | Corynebacterium sp. |