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Literature summary for 1.1.1.34 extracted from

  • Nieto, B.; Fores, O.; Arro, M.; Ferrer, A.
    Arabidopsis 3-hydroxy-3-methylglutaryl-CoA reductase is regulated at the post-translational level in response to alterations of the sphingolipid and the sterol biosynthetic pathways (2009), Phytochemistry, 70, 53-59.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
squalestatin leads to a significant concentration-dependent activation of HMGR of ca. 3fold the activity in untreated plants. Maximal HMGR activation at 0.06 mM squalestatin. No relevant changes in the level of expression of the HMG genes or in the amount of HMGR protein Arabidopsis thaliana
terbinafine leads to a significant concentration-dependent activation of HMGR of ca. 3fold the activity in untreated plants. Maximal HMGR activation at 0.75 mM terbinafine. No relevant changes in the level of expression of the HMG genes or in the amount of HMGR protein Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
additional information whether plants are grown with mevalonate from the beginning or only during the last 9 days, HMGR activity is drastically reduced to 25% of the activity in plants grown in the absence of mevalonate. Plants grown without mevalonate during the last 9 days show a severe, though less pronounced, reduction in HMGR activity, which decreases to 60% of the activity in control plants. Significant reduction of HMGR activity does not correlate with changes in both the expression of HMG1 and HMG2 genes and the amount of HMGR protein Arabidopsis thaliana
myriocin concomitant reduction of both HMGR activity and the sterol content by depletion of the sphingolipid pathway. At 0.01 mM myriocin decrease to ca. 55% of the HMGR activity in control plants. Myriocin-induced down-regulation of HMGR activity is exerted at the post-translational level, like the regulatory response of HMGR to enhancement or depletion of the flux through the sterol pathway Arabidopsis thaliana

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
63000
-
immunoblot analysis, isoform HMGR1S Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-hydroxy-3-methylglutaryl-CoA + NADPH Arabidopsis thaliana up- and down-regulation of HMGR activity in response to changes in the flux of the mevalonate pathway occur via post-translational control mevalonate + CoA + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxy-3-methylglutaryl-CoA + NADPH up- and down-regulation of HMGR activity in response to changes in the flux of the mevalonate pathway occur via post-translational control Arabidopsis thaliana mevalonate + CoA + NADP+
-
?

Synonyms

Synonyms Comment Organism
HMG1
-
Arabidopsis thaliana
HMG2
-
Arabidopsis thaliana
HMGR
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Arabidopsis thaliana