Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.34 extracted from

  • Schiefelbein, D.; Goren, I.; Fisslthaler, B.; Schmidt, H.; Geisslinger, G.; Pfeilschifter, J.; Frank, S.
    Biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses (2008), J. Biol. Chem., 283, 15479-15490.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
simvastatin enzyme inhibition causes 40% reduction of wound healing, inhibition of HMGR activity during acute wound healing interferes with keratinocyte VEGF production and proliferation at the wound site, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hydroxymethylglutaryl-CoA + NADPH + H+ Mus musculus
-
mevalonate + NADP+ + CoA
-
?
hydroxymethylglutaryl-CoA + NADPH + H+ Mus musculus C57/BL6J
-
mevalonate + NADP+ + CoA
-
?
additional information Mus musculus biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses, overview ?
-
?
additional information Mus musculus C57/BL6J biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
C57BL/6J mice
-
Mus musculus C57/BL6J
-
C57BL/6J mice
-

Source Tissue

Source Tissue Comment Organism Textmining
keratinocyte
-
Mus musculus
-
skin from tail Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hydroxymethylglutaryl-CoA + NADPH + H+
-
Mus musculus mevalonate + NADP+ + CoA
-
?
hydroxymethylglutaryl-CoA + NADPH + H+
-
Mus musculus C57/BL6J mevalonate + NADP+ + CoA
-
?
additional information biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses, overview Mus musculus ?
-
?
additional information biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses, overview Mus musculus C57/BL6J ?
-
?

Synonyms

Synonyms Comment Organism
HMGR
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Mus musculus