Literature summary for 1.1.1.34 extracted from

Ness, G.C.; Holland, R.C.; Lopez, D.
Selective compensatory induction of hepatic HMG-CoA reductase in response to inhibition of cholesterol absorption (2006), Exp. Biol. Med., 231, 559-565.

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Application

Application	Comment	Organism
medicine	the cholesterol absorption inhibitor ezetimibe profoundly lowers serum cholesterol levels in animals expressing very low rates of hepatic cholesterol synthesis and produces large compensatory increases in hepatic HMG-CoA reductase expression without signifucantly affecting expression of hepatic low density lipoprotein receptors. This indicates that ezitimibe should be most effective in lowering serum cholesterol levels in peaple with low rates of cholesterol synthesis/High rates of cholesterol absorption	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P51639	young male Sprague-Dawley	-

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Release 2023.1 (January 2023)