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Literature summary for 1.1.1.34 extracted from
- Induction mechanism of 3-hydroxy-3-methylglutaryl-CoA reductase in potato tuber and sweet potato root tissues (2003), Biosci. Biotechnol. Biochem., 67, 1007-1017.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | 4fold enzyme induction by root cutting within 2 h, and strong induction by infection with Phytophtora infestans, maximal 66fold after 2 h, induction mechanism | Ipomoea batatas | |
| additional information | about 40fold enzyme induction by root cutting within 14 h, and about 875fold induction by infection with Phytophtora infestans after 22 h, induction mechanism | Solanum tuberosum |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the hybrid is resistant to race 0 of Phytophtora infestans | Solanum x edinense |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Solanum tuberosum | - |
- |
| microsome | - |
Ipomoea batatas | - |
- |
| microsome | - |
Solanum x edinense | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Hg2+ | induces the enzyme in cut roots treated with HgCl2 | Ipomoea batatas |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | Solanum tuberosum | - |
(R)-mevalonate + CoA + 2 NADP+ | - |
r | |
| (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | Ipomoea batatas | - |
(R)-mevalonate + CoA + 2 NADP+ | - |
r | |
| (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | Solanum x edinense | - |
(R)-mevalonate + CoA + 2 NADP+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ipomoea batatas | - |
cv. Norin 1 | - |
| Solanum tuberosum | - |
cv. Irish Cobbler | - |
| Solanum x edinense | - |
cv. Rishiri, interspecific hybrid | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | regulation of the plant enzyme by phosphorylation/dephosphorylation | Solanum tuberosum |
| phosphoprotein | regulation of the plant enzyme by phosphorylation/dephosphorylation | Ipomoea batatas |
| phosphoprotein | regulation of the plant enzyme by phosphorylation/dephosphorylation | Solanum x edinense |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 4380fold to homogeneity from microsomes by solubilization with trypsin, and affinity chromatography on 2',5'-ADP-resin and HMG-CoA-hexane resin | Solanum tuberosum |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| root | - |
Ipomoea batatas | - |
| tuber | - |
Solanum tuberosum | - |
| tuber | - |
Solanum x edinense | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Ipomoea batatas |
| 7800 | - |
purified enzyme | Solanum tuberosum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | - |
Solanum tuberosum | (R)-mevalonate + CoA + 2 NADP+ | - |
r | |
| (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | - |
Ipomoea batatas | (R)-mevalonate + CoA + 2 NADP+ | - |
r | |
| (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | - |
Solanum x edinense | (R)-mevalonate + CoA + 2 NADP+ | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3-hydroxy-3-methylglutaryl-CoA reductase | - |
Solanum tuberosum |
| 3-hydroxy-3-methylglutaryl-CoA reductase | - |
Ipomoea batatas |
| 3-hydroxy-3-methylglutaryl-CoA reductase | - |
Solanum x edinense |
| HMGR | - |
Solanum tuberosum |
| HMGR | - |
Ipomoea batatas |
| HMGR | - |
Solanum x edinense |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Solanum tuberosum |
| 30 | - |
assay at | Ipomoea batatas |
| 30 | - |
assay at | Solanum x edinense |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Solanum tuberosum |
| 7.5 | - |
assay at | Ipomoea batatas |
| 7.5 | - |
assay at | Solanum x edinense |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Solanum tuberosum | |
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