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Literature summary for 1.1.1.34 extracted from

  • Friesen, J.A.; Rodwell, V.W.
    Identification of elements critical for phosphorylation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by adenosine monophosphate-activated protein kinase: Protein engineering of the naturally nonephosphorylatable 3-hydroxy-3-methylglutaryl coenzyme A reductase from Pseudomonas mevalonii (1997), Biochemistry, 36, 1157-1162.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Pseudomonas mevalonii

Protein Variants

Protein Variants Comment Organism
R387S regulation of activity by phosphorylation Pseudomonas mevalonii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-hydroxy-3-methylglutaryl-CoA + NADPH Pseudomonas mevalonii
-
(R)-mevalonate + CoA + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Pseudomonas mevalonii
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxy-3-methylglutaryl-CoA + NADPH
-
Pseudomonas mevalonii (R)-mevalonate + CoA + NADP+
-
?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Pseudomonas mevalonii