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Literature summary for 1.1.1.34 extracted from

  • Hupperich, M.; Thomer, A.; Kratz, K.; Eggerer, H.
    Substrate and inhibitor specificity of 3-hydroxy-3-methylglutaryl-CoA reductase determined with substrate-analogue CoA-thioesters and CoA-thioethers (1991), Biol. Chem. Hoppe-Seyler, 372, 857-863.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
(S)-4-carboxy-3-hydroxy-3-methylbutyryl-CoA competitive inhibitor Homo sapiens
(S)-4-carboxy-3-hydroxybutyryl-CoA competitive inhibitor Homo sapiens
3,3-dimethylglutaryl-CoA competitive inhibitor Homo sapiens
3-hydroxyglutaryl-CoA competitive inhibitor Homo sapiens
3-methylglutaryl-CoA competitive inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-hydroxy-3-methylglutaryl-CoA + NADPH Homo sapiens
-
 (R)-mevalonate + CoA + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxy-3-methylglutaryl-CoA + NADPH
-
 Homo sapiens (R)-mevalonate + CoA + NADP+
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens