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Literature summary for 1.1.1.34 extracted from
- Solubilization and purification of beta-hydroxy-beta-methylglutaryl coenzyme A reductase from rat liver (1970), Biochemistry, 9, 1700-1705.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Rattus norvegicus |  |
| acetoacetyl-CoA | - |
Rattus norvegicus | |
| acetyl-CoA | - |
Rattus norvegicus | |
| CoASH | - |
Rattus norvegicus | |
| deoxycholate | - |
Rattus norvegicus | |
| digitonine | 2% digitonin, 80% inhibition | Rattus norvegicus | |
| Fe2+ | - |
Rattus norvegicus | |
| Fe3+ | - |
Rattus norvegicus | |
| p-hydroxymercuribenzoate | 0.01 mM inhibited 97% of reduction | Rattus norvegicus | |
| SDS | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.006 | - |
3-hydroxy-3-methylglutaryl-CoA | only one enantiomer | Rattus norvegicus | |
| 0.012 | - |
3-hydroxy-3-methylglutaryl-CoA | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 217000 | 226000 | gel filtration, ultracentrifugation | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-CoA + NADPH | Rattus norvegicus | - |
(R)-mevalonate + CoA + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.03 | - |
- |
Rattus norvegicus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -10°C, crude microsomal form, 10-20% loss of activity per week | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Rattus norvegicus | (R)-mevalonate + CoA + NADP+ | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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