Application | Comment | Organism |
---|---|---|
diagnostics | the wecC gene may represent a useful method for detecting the human type of Edwardsiella tarda, which may have the ability to cause human infection | Edwardsiella tarda |
Cloned (Comment) | Organism |
---|---|
gene wecC, genotyping | Edwardsiella tarda |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Edwardsiella tarda | - |
22 strains of Edwardsiella tarda, including 10 human isolates and 12 diseased fish isolates | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | pathogen cell culture in human Caco-2 cell monolyers | Edwardsiella tarda | - |
Synonyms | Comment | Organism |
---|---|---|
wecC | - |
Edwardsiella tarda |
General Information | Comment | Organism |
---|---|---|
evolution | Edwardsiella tarda strains can be grouped into two types of human isolates and diseased fish isolates based on distribution of the wecC gene, type III and type VI secretion system genes, the groups are broadly clustered into two major subpopulations: EdwGI and EdwGII. Edwardsiella tarda EdwGI is composed of strains mainly isolated from fish, such as the turbot, striped bass, and Japanese eel, represents a genotype of fish pathogens, and possesses virulence-associated gene clusters such as T3SS and T6SS. Edwardsiella tarda EdwGII contains strains isolated from human feces, nonpathogenic strains to fish, and environmental strains, and lacks some important virulence-associated gene clusters including T3SS and T6SS | Edwardsiella tarda |
malfunction | motility activity, including swarming and swimming, of the wecC mutant is weaker than that f the wild-type strain | Edwardsiella tarda |
physiological function | the enzyme is involved in synthesis of enterobacterial common antigen. The swarming and swimming abilities mediated by the wecC and fliF genes appears to be essential for penetration activity of Edwardsiella tarda through Caco-2 cell monolayers | Edwardsiella tarda |