Literature summary for 1.1.1.332 extracted from

Fabian, S.J.; Maust, M.D.; Panaccione, D.G.
Ergot alkaloid synthesis capacity of Penicillium camemberti (2018), Appl. Environ. Microbiol., 84, e01583-18 .

Search for more literature for 1.1.1.332

Cloned(Commentary)

Cloned (Comment)	Organism
gene easD or fgaDH, ergot alkaloid synthesis (eas) genes are found clustered in the genomes of ergot alkaloid-producing fungi, genetic structure	Aspergillus fumigatus
gene easD, ergot alkaloid synthesis (eas) genes are found clustered in the genomes of ergot alkaloid-producing fungi, genetic structure, DNA and amino acid sequence determination and comparison with the enzyme sequence from Penicilium biforme. The Penicillium camemberti genome contains a cluster of genes containing homologues to several eas genes and has or had (at one time in its evolutionary past) the ability to produce ergot alkaloids, expression analysis, the mRNAs are processed properly, as the cDNAs contain open reading frames, expression analysis	Penicillium camemberti

Cloned (Comment)

Organism

gene easD or fgaDH, ergot alkaloid synthesis (eas) genes are found clustered in the genomes of ergot alkaloid-producing fungi, genetic structure

Aspergillus fumigatus

gene easD, ergot alkaloid synthesis (eas) genes are found clustered in the genomes of ergot alkaloid-producing fungi, genetic structure, DNA and amino acid sequence determination and comparison with the enzyme sequence from Penicilium biforme. The Penicillium camemberti genome contains a cluster of genes containing homologues to several eas genes and has or had (at one time in its evolutionary past) the ability to produce ergot alkaloids, expression analysis, the mRNAs are processed properly, as the cDNAs contain open reading frames, expression analysis

Penicillium camemberti

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.
chanoclavine-I + NAD+	Aspergillus fumigatus	-	chanoclavine-I aldehyde + NADH + H+	-	r
chanoclavine-I + NAD+	Aspergillus fumigatus CBS 101355	-	chanoclavine-I aldehyde + NADH + H+	-	r
chanoclavine-I + NAD+	Aspergillus fumigatus ATCC MYA-4609	-	chanoclavine-I aldehyde + NADH + H+	-	r
chanoclavine-I + NAD+	Aspergillus fumigatus FGSC A1100	-	chanoclavine-I aldehyde + NADH + H+	-	r
chanoclavine-I + NAD+	Aspergillus fumigatus Af293	-	chanoclavine-I aldehyde + NADH + H+	-	r

Organism

Organism	UniProt	Comment	Textmining
Aspergillus fumigatus	Q4WZ66	Aspergillus fumigatus	-
Aspergillus fumigatus Af293	Q4WZ66	Aspergillus fumigatus	-
Aspergillus fumigatus ATCC MYA-4609	Q4WZ66	Aspergillus fumigatus	-
Aspergillus fumigatus CBS 101355	Q4WZ66	Aspergillus fumigatus	-
Aspergillus fumigatus FGSC A1100	Q4WZ66	Aspergillus fumigatus	-
Penicillium camemberti	-	-	-
Penicillium camemberti NRRL 874	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
chanoclavine-I + NAD+	-	Penicillium camemberti	chanoclavine-I aldehyde + NADH + H+	-	r
chanoclavine-I + NAD+	-	Aspergillus fumigatus	chanoclavine-I aldehyde + NADH + H+	-	r
chanoclavine-I + NAD+	-	Aspergillus fumigatus CBS 101355	chanoclavine-I aldehyde + NADH + H+	-	r
chanoclavine-I + NAD+	-	Aspergillus fumigatus ATCC MYA-4609	chanoclavine-I aldehyde + NADH + H+	-	r
chanoclavine-I + NAD+	-	Aspergillus fumigatus FGSC A1100	chanoclavine-I aldehyde + NADH + H+	-	r
chanoclavine-I + NAD+	-	Aspergillus fumigatus Af293	chanoclavine-I aldehyde + NADH + H+	-	r
chanoclavine-I + NAD+	-	Penicillium camemberti NRRL 874	chanoclavine-I aldehyde + NADH + H+	-	r

Synonyms

Synonyms	Comment	Organism
ChaDH	-	Penicillium camemberti
ChaDH	-	Aspergillus fumigatus
easD	-	Penicillium camemberti
easD	-	Aspergillus fumigatus
fgaDH	-	Aspergillus fumigatus

Cofactor

Cofactor	Comment	Organism
NAD+	-	Penicillium camemberti
NAD+	-	Aspergillus fumigatus
NADH	-	Penicillium camemberti
NADH	-	Aspergillus fumigatus

General Information

General Information	Comment	Organism
metabolism	the enzyme is involved in the biosynthesis of festuclavine from dimethylallylpyrosphosphate and tryptophane, the ergot alkaloid pathway, overview. The product of the easD reaction, chanoclavine-I aldehyde, serves as a branch point intermediate that may be acted on by the products of different alleles of ergot alkaloid synthesis genes in different lineages to yield lysergic acid and its derivatives in the Clavicipitaceae or various clavine-type ergot alkaloids in the Eurotiales (including Neosartorya and Penicillium species)	Penicillium camemberti
metabolism	the enzyme is involved in the biosynthesis of festuclavine from dimethylallylpyrosphosphate and tryptophane, the ergot alkaloid pathway, overview. The product of the easD reaction, chanoclavine-I aldehyde, serves as a branch point intermediate that may be acted on by the products of different alleles of ergot alkaloid synthesis genes in different lineages to yield lysergic acid and its derivatives in the Clavicipitaceae or various clavine-type ergot alkaloids in the Eurotiales (including Neosartorya and Penicillium species)	Aspergillus fumigatus
physiological function	the clavine alkaloids of the animal pathogen Neosartorya fumigata (Aspergillus fumigatus) contribute to virulence	Aspergillus fumigatus