Cloned (Comment) | Organism |
---|---|
expression in Sf9 cell | Homo sapiens |
expression in Sf9 cell | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | Q8VCH7 | - |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
24000 | - |
substrate 11-cis-retinol, pH 7.4, 37°C | Homo sapiens |
81000 | - |
substrate 9-cis-retinol, pH 7.4, 37°C | Homo sapiens |
124000 | - |
substrate all-trans-retinol, pH 7.4, 37°C | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-cis-retinol + NAD+ | - |
Homo sapiens | 11-cis-retinal + NADH + H+ | - |
? | |
9-cis-retinol + NADP+ | - |
Homo sapiens | 9-cis-retinal + NADPH + H+ | - |
? | |
all-trans-retinol + NADP+ | - |
Homo sapiens | all-trans-retinal + NADPH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RDH10 | - |
Homo sapiens |
RDH10 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | no detectable activity with NADP+ | Homo sapiens | |
additional information | no detectable activity with NADP+ | Mus musculus | |
NAD+ | - |
Homo sapiens | |
NAD+ | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | mice with a conditional knock-out of isoform Rdh10 in retinal pigmented epithelium cells display delayed 11-cis-retinal regeneration and dark adaption after bright light illumination. Retinal function after light exposure is also delayed in Rdh10 KO mice as compared with controls. Double deletion of isoforms Rdh5 and Rdh10 in mice causes elevated 11/13-cis-retinyl ester content also seen in Rdh5-/- Rdh11-/- mice as compared with Rdh5-/- mice. Normal retinal morphology is observed in 6-month-old Rdh10 KO and Rdh5 and Rdh10 KO mice | Mus musculus |