Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
additional information | the enzyme is located at the mid-piece (a specialized development from the mitochondria) of elongating, elongated, and mature sperm | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-hydroxy-2-methylpropanoate + NAD+ | Homo sapiens | - |
2-methyl-3-oxopropanoate + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cerebellum | - |
Homo sapiens | - |
heart | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
additional information | HIBADH is downregulated in low-motility sperm, and is enriched expressed during human spermiogenesis, quantitative RT-PCR expression analysis, overview | Homo sapiens | - |
neuronal cell | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |
skeletal muscle | - |
Homo sapiens | - |
sperm | elongating, elongated, and mature sperm | Homo sapiens | - |
testis | - |
Homo sapiens | - |
uterus | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-hydroxy-2-methylpropanoate + NAD+ | - |
Homo sapiens | 2-methyl-3-oxopropanoate + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HIBADH | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
20 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
10 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | HIBADH is downregulated in low-motility sperm, and is enriched expressed during human spermiogenesis | down |
Homo sapiens | HIBADH is downregulated in low-motility sperm, and is enriched expressed during human spermiogenesis | up |
General Information | Comment | Organism |
---|---|---|
evolution | 3-hydroxyisobutyrate dehydrogenase belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donors with NAD+ or NADP+ acceptors | Homo sapiens |
additional information | enzyme activity of HIBADH in spermatozoa from patients with asthenozoospermia is reduced compared to controls | Homo sapiens |
physiological function | 3-hydroxyisobutyrate dehydrogenase is one of the critical enzymes generating glucose by metabolizing amino acids in the gluconeogenesis pathway. It participates in valine, leucine, and isoleucine degradation and is a central metabolic enzyme in the valine catabolic pathway. The enzyme plays an important role in regulating sperm motility and may serve as a novel sperm-motility marker | Homo sapiens |