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Literature summary for 1.1.1.300 extracted from

  • Chen, C.; Thompson, D.A.; Koutalos, Y.
    Reduction of all-trans-retinal in vertebrate rod photoreceptors requires the combined action of RDH8 and RDH12 (2012), J. Biol. Chem., 287, 24662-24670.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.300

Localization

Localization Comment Organism GeneOntology No. Textmining
photoreceptor inner segment
-
 Mus musculus 1917
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
all-trans-retinol + NADP+ Mus musculus
-
 all-trans-retinal + NADPH + H+
-
 ?
all-trans-retinol + NADP+ Mus musculus C57BL/6 x 129/Sv
-
 all-trans-retinal + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus C57BL/6 x 129/Sv
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
eye RDH12 localizes to photoreceptor inner segments Mus musculus
-
retina
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
all-trans-retinol + NADP+
-
 Mus musculus all-trans-retinal + NADPH + H+
-
 ?
all-trans-retinol + NADP+
-
 Mus musculus C57BL/6 x 129/Sv all-trans-retinal + NADPH + H+
-
 ?
additional information no activity with decanal Mus musculus ?
-
 ?
additional information no activity with decanal Mus musculus C57BL/6 x 129/Sv ?
-
 ?

Synonyms

Synonyms Comment Organism
RDH12
-
 Mus musculus
retinoid dehydrogenase/reductase
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Mus musculus

General Information

General Information Comment Organism
evolution RDHs that catalyze the interconversion of retinal and retinol involved in rhodopsin turnover are members of the family of short chain dehydrogenase/reductases Mus musculus
malfunction loss-of-function mutations of RDH12 cause retinal degeneration in some forms of Leber congenital amaurosis. Outer segments of rods deficient in Rdh12 show no altered phenotype. Following exposure to light, a leak of retinoids from outer to inner segments is detected in rods from both wild-type and knock-out mice. In cells lacking Rdh8, EC 1.1.1.105, or Rdh12, this leak is mainly all-trans-retinal, overview. Retinal reductase activity is lost in RDH8-deficient mutants Mus musculus
physiological function RDH12 activity in the photoreceptor inner segments is also key enzyme function. RDH12 in inner segments can protect vital cell organelles against aldehyde toxicity caused by an intracellular leak of all-trans-retinal, as well as other aldehydes originating both inside and outside the cell Mus musculus