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Literature summary for 1.1.1.300 extracted from

  • Maeda, A.; Maeda, T.; Sun, W.; Zhang, H.; Baehr, W.; Palczewski, K.
    Redundant and unique roles of retinol dehydrogenases in the mouse retina (2007), Proc. Natl. Acad. Sci. USA, 104, 19565-19570.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
all-trans-retinal + NADPH + H+ Mus musculus RDH12 is dispensable in support of the visual cycle but appears to be a key component in clearance of free all-trans-retinal, thereby preventing accumulation of N-retinylidene-N-retinylethanolamine (a toxic substance known to contribute to retinal degeneration) and photoreceptor cell death all-trans-retinol + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8BYK4
-
-

Source Tissue

Source Tissue Comment Organism Textmining
retina
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
all-trans-retinal + NADPH + H+
-
Mus musculus all-trans-retinol + NADP+
-
?
all-trans-retinal + NADPH + H+ RDH12 is dispensable in support of the visual cycle but appears to be a key component in clearance of free all-trans-retinal, thereby preventing accumulation of N-retinylidene-N-retinylethanolamine (a toxic substance known to contribute to retinal degeneration) and photoreceptor cell death Mus musculus all-trans-retinol + NADP+
-
?

Synonyms

Synonyms Comment Organism
RDH12
-
Mus musculus