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Literature summary for 1.1.1.30 extracted from

  • Dubois, H.; Fritsche, T.M.; Trommer, W.E.; McIntyre, J.O.; Fleischer, S.
    Cyanylation of 3-hydroxybutyrate dehydrogenase (1986), Biol. Chem. Hoppe-Seyler, 367, 343-353.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
phosphatidylcholine
-
Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
3-hydroxybutyrate substrate inhibition at concentrations above 20 mM, 50% inhibition at 200 mM, cyanylated enzyme is 3fold more active at high substrate concentration Bos taurus
4-mercapto-3-nitrobenzoate derivatization of enzyme sulfhydryl groups, less than 1% residual activity Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.091
-
NADH
-
Bos taurus
0.164
-
NADH cyanylated enzyme Bos taurus
0.55
-
NAD+
-
Bos taurus
0.59
-
acetoacetate
-
Bos taurus
0.902
-
NAD+ cyanylated enzyme Bos taurus
2.3
-
(R)-3-hydroxybutanoate
-
Bos taurus
8.7
-
acetoacetate cyanylated enzyme Bos taurus
21
-
(R)-3-hydroxybutanoate cyanylated enzyme Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Bos taurus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-3-hydroxybutanoate + NAD+ Bos taurus
-
acetoacetate + NADH
-
r

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-3-hydroxybutanoate + NAD+
-
Bos taurus acetoacetate + NADH
-
r
(R)-3-hydroxybutanoate + NAD+
-
Bos taurus acetoacetate + NADH + H+
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Bos taurus