Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ADP | competitive with respect to NAD+, noncompetitive with respect to S-hydroxymethylglutathione | [Candida] boidinii | |
AMP | competitive with respect to NAD+, noncompetitive with respect to S-hydroxymethylglutathione | [Candida] boidinii | |
ATP | competitive with respect to NAD+, noncompetitive with respect to S-hydroxymethylglutathione | [Candida] boidinii | |
NADH | - |
[Candida] boidinii | |
S-formylglutathione | - |
[Candida] boidinii | |
S-hydroxymethylglutathione | - |
[Candida] boidinii |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
formaldehyde + glutathione + NAD+ | [Candida] boidinii | key enzyme of the dissimilatory pathway of the methanol metabolism | S-formylglutathione + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
[Candida] boidinii | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+ | ordered bi-bi mechanism | [Candida] boidinii |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
formaldehyde + glutathione + NAD+ | the true substrate is a hemimercaptal, S-hydroxymethylglutathione, spontaneously formed from formaldehyde and glutathione | [Candida] boidinii | S-formylglutathione + NADH + H+ | - |
r | |
formaldehyde + glutathione + NAD+ | key enzyme of the dissimilatory pathway of the methanol metabolism | [Candida] boidinii | S-formylglutathione + NADH + H+ | - |
? | |
S-formylglutathione + NADH | - |
[Candida] boidinii | formaldehyde + glutathione + NAD+ | - |
r |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
[Candida] boidinii | |
NADH | - |
[Candida] boidinii |