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Literature summary for 1.1.1.284 extracted from

  • Goodman, J.I.; Tephly, T.R.
    A comparison of rat and human liver formaldehyde dehydrogenase (1971), Biochim. Biophys. Acta, 252, 489-505.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
pyrazole stimulates Rattus norvegicus
pyrazole no effect Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
folic acid
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.007
-
NAD+
-
Homo sapiens
0.0071
-
formaldehyde
-
Rattus norvegicus
0.0087
-
formaldehyde
-
Homo sapiens
0.01
-
NAD+
-
Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
additional information contains metal Homo sapiens
additional information does not contain metal Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
90000
-
gel filtration Homo sapiens
110000
-
gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.092
-
-
Rattus norvegicus
0.225
-
-
Homo sapiens

Storage Stability

Storage Stability Organism
0-5°C, when EDTA and dithiothreitol are used throughout the purification procedure, stable for at least 3 weeks Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
formaldehyde + glutathione + NAD+
-
Homo sapiens S-formylglutathione + NADH + H+
-
?
formaldehyde + glutathione + NAD+
-
Rattus norvegicus S-formylglutathione + NADH + H+
-
?

Subunits

Subunits Comment Organism
More the enzyme exists in a complex with other proteins or in a polymeric form until the ultimate steps in purification Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 8.4
-
Rattus norvegicus
7.6 8.8
-
Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
6.5 9.5 pH 6.5: about 70% of maximal activity, pH 9.5: about 80% of maximal activity Homo sapiens
6.8 9.3 pH 6.8: about 80% of maximal activity, pH 9.3: about 90% of maximal activity Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NAD+
-
Rattus norvegicus
NADP+ no activity with NADP+ Homo sapiens
NADP+ no activity with NADP+ Rattus norvegicus