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Literature summary for 1.1.1.28 extracted from
- D(-)-lactate dehydrogenase from fungi (1975), Methods Enzymol., 41B, 293-298.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| fructose 1,6-diphosphate | - |
Globisporangium debaryanum |  |
| fructose 1,6-diphosphate | - |
Sapromyces elongatus | |
| fructose 1,6-diphosphate | - |
Elongisporangium undulatum | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 98000 | - |
sucrose density gradient sedimentation | Globisporangium debaryanum |
| 115000 | - |
gel filtration | Globisporangium debaryanum |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (R)-lactate + NAD+ | Globisporangium debaryanum | - |
pyruvate + NADH | - |
r | |
| (R)-lactate + NAD+ | Sapromyces elongatus | - |
pyruvate + NADH | - |
r | |
| (R)-lactate + NAD+ | Elongisporangium undulatum | - |
pyruvate + NADH | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Elongisporangium undulatum | - |
- |
- |
| Globisporangium debaryanum | - |
- |
- |
| Sapromyces elongatus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Globisporangium debaryanum |
- |
Sapromyces elongatus |
- |
Elongisporangium undulatum |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| (R)-lactate + NAD+ = pyruvate + NADH + H+ | binary-binary mechanism with either NAD+ or NADH as the first substrate | Globisporangium debaryanum | |
| (R)-lactate + NAD+ = pyruvate + NADH + H+ | binary-binary mechanism with either NAD+ or NADH as the first substrate | Sapromyces elongatus | |
| (R)-lactate + NAD+ = pyruvate + NADH + H+ | binary-binary mechanism with either NAD+ or NADH as the first substrate | Elongisporangium undulatum |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mycelium | - |
Globisporangium debaryanum | - |
| mycelium | - |
Sapromyces elongatus | - |
| mycelium | - |
Elongisporangium undulatum | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, for at least 2 years | Globisporangium debaryanum |
| -20°C, for at least 2 years | Sapromyces elongatus |
| -20°C, for at least 2 years | Elongisporangium undulatum |
| 4°C, several weeks | Globisporangium debaryanum |
| 4°C, several weeks | Sapromyces elongatus |
| 4°C, several weeks | Elongisporangium undulatum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (R)-lactate + NAD+ | - |
Globisporangium debaryanum | pyruvate + NADH | - |
r | |
| (R)-lactate + NAD+ | - |
Sapromyces elongatus | pyruvate + NADH | - |
r | |
| (R)-lactate + NAD+ | - |
Elongisporangium undulatum | pyruvate + NADH | - |
r | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Globisporangium debaryanum | |
| NAD+ | - |
Sapromyces elongatus | |
| NAD+ | - |
Elongisporangium undulatum | |
| NADH | - |
Globisporangium debaryanum | |
| NADH | - |
Sapromyces elongatus | |
| NADH | - |
Elongisporangium undulatum | |
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