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Literature summary for 1.1.1.270 extracted from

  • Layer, J.; Barnes, B.; Yamasaki, Y.; Barbuch, R.; Li, L.; Taramino, S.; Balliano, G.; Bard, M.
    Characterization of a mutation that results in independence of oxidosqualene cyclase (Erg7) activity from the downstream 3-ketoreductase (Erg27) in the yeast ergosterol biosynthetic pathway (2013), Biochim. Biophys. Acta, 1831, 361-369.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus O88736
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-

Synonyms

Synonyms Comment Organism
Erg27
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Mus musculus
Hsd17
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Mus musculus

General Information

General Information Comment Organism
physiological function expression of mouse mouse 3-keto-steroid reductase Erg27 in a Saccharomyces cerevisiae Erg27 mutant confers the ability to grow using lanosterol as a substrate. The mouse orthologue complements the erg27 lesion but is unable to restore Erg7, i.e. lanosterol synthase, activity. The recombinant strain accumulates squalene epoxides, 3-ketosterones, and ergosterol Mus musculus