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Literature summary for 1.1.1.270 extracted from

  • Taramino, S.; Teske, B.; Oliaro-Bosso, S.; Bard, M.; Balliano, G.
    Divergent interactions involving the oxidosqualene cyclase and the steroid-3-ketoreductase in the sterol biosynthetic pathway of mammals and yeasts (2010), Biochim. Biophys. Acta, 1801, 1232-1237.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information overexpression of 17beta-hydroxysteroid dehydrogenase type 7 in ERG27-deleted yeast cells. Recombinant strains grow more slowly than the control yeast ERG27-overexpressing strain on sterol-deficient media, whereas the growth rate is normal on media supplemented with a 3-ketoreductase substrate. Mammalian steroid-3-ketoreductase expressed in yeast shows full enzymatic functioanlity but is unable to support the functionality of yeast oxidosqualene cyclase as ERG27 does Mus musculus
additional information overexpression of 17beta-hydroxysteroid dehydrogenase type 7 in ERG27-deleted yeast cells. Recombinant strains grow more slowly than the control yeast ERG27-overexpressing strain on sterol-deficient media, whereas the growth rate is normal on media supplemented with a 3-ketoreductase substrate. Mammalian steroid-3-ketoreductase expressed in yeast shows full enzymatic functioanlity but is unable to support the functionality of yeast oxidosqualene cyclase as ERG27 does Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P56937
-
-
Mus musculus O88736
-
-

Source Tissue

Source Tissue Comment Organism Textmining
NS0 cell
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
17beta-hydroxysteroid dehydrogenase type 7
-
Mus musculus
17beta-hydroxysteroid dehydrogenase type 7
-
Homo sapiens

General Information

General Information Comment Organism
physiological function in NS0 cells deficient in 17beta-hydroxysteroid dehydrogenase type 7 activity, oxidosqualene cyclase is fully active. The protective role of the 3-ketoreductase in yeasts with respect to oxidosqualene cyclase activity is not conserved in mammals Mus musculus