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Literature summary for 1.1.1.270 extracted from

  • Marijanovic, Z.; Laubner, D.; Moeller, G.; Gege, C.; Husen, B.; Adamski, J.; Breitling, R.
    Closing the gap: Identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis (2003), Mol. Endocrinol., 17, 1715-1725.
    View publication on PubMed
Search for more literature for 1.1.1.270

Cloned(Commentary)

Cloned (Comment) Organism
expression of HSD17B7 and truncated HSD17B7 (shortened by 127 amino acids at the C terminus) as glutathione-S-transferase fusion protein in Escherichia coli. Erg27p-deficient yeast strain complements the 3-ketosteroid reductase deficiency of the cells and restores growth on sterol-deficient medium Homo sapiens
expression of HSD17B7 as a glutathione-S-transferase fusion protein in Escherichia coli. Erg27p-deficient yeast strain complements the 3-ketosteroid reductase deficiency of the cells and restores growth on sterol-deficient medium Mus musculus

Protein Variants

Protein Variants Comment Organism
DELTA214-341 inactive mutant enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Mus musculus 5783
-
endoplasmic reticulum
-
 Homo sapiens 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus HSD17B7 participates in postsqualene cholesterol biosynthesis ?
-
 ?
additional information Homo sapiens HSD17B7 participates in postsqualene cholesterol biosynthesis, HSD17B7 is a novel candidate for inborn errors of cholesterol metabolism ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo high expression levels in the ganglion of the trigeminal nerve and the dorsal root ganglia Mus musculus
-
ganglion of the trigeminal nerve, dorsal root ganglia, cranial ganglia Mus musculus
-
additional information specifically expressed in tissues that are involved in the pathogenesis of congenital cholesterol-deficiency disorders Mus musculus
-
neural tube
-
 Mus musculus
-
tail bud
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information HSD17B7 participates in postsqualene cholesterol biosynthesis Mus musculus ?
-
 ?
additional information HSD17B7 participates in postsqualene cholesterol biosynthesis, HSD17B7 is a novel candidate for inborn errors of cholesterol metabolism Homo sapiens ?
-
 ?
zymosterone + NADPH
-
 Mus musculus zymosterol + NADP+
-
 ?
zymosterone + NADPH
-
 Homo sapiens zymosterol + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
HSD17B7
-
 Mus musculus
HSD17B7
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Mus musculus
NADPH
-
 Homo sapiens