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Literature summary for 1.1.1.270 extracted from

  • Vanden Bossche, H.; Marichal, P.; Le Jeune, L.; Coene, M.C.; Gorrens, J.; Cools, W.
    Effects of itraconazole on cytochrome P-450-dependent sterol 14alpha-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans (1993), Antimicrob. Agents Chemother., 37, 2101-2105.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
itraconazole triazole antifungal agent, inhibits NADPH-dependent 3-ketosteroid reductase directly or indirectly Cryptococcus neoformans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Cryptococcus neoformans enzyme of sterol, ergosterol, biosynthesis, enzyme catalyzes last step in demethylation at C-4 ?
-
?

Organism

Organism UniProt Comment Textmining
Cryptococcus neoformans
-
var. neoformans, B42419, ATCC 32265, pathogenic fungus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information NADPH-dependent 3-ketosteroid reductase catalyzes reduction of the 3-keto group to a 3beta-hydroxyl group Cryptococcus neoformans ?
-
?
additional information enzyme of sterol, ergosterol, biosynthesis, enzyme catalyzes last step in demethylation at C-4 Cryptococcus neoformans ?
-
?
obtusifolione + NADPH 4,14-dimethyl-ergosta-8,24(28)-dien-3-one Cryptococcus neoformans obtusifoliol + NADP+ 4,14-dimethyl-ergosta-8,24(28)-dien-3-ol ?

Cofactor

Cofactor Comment Organism Structure
NADPH NADPH-dependent Cryptococcus neoformans