Inhibitors | Comment | Organism | Structure |
---|---|---|---|
itraconazole | triazole antifungal agent, inhibits NADPH-dependent 3-ketosteroid reductase directly or indirectly | Cryptococcus neoformans |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Cryptococcus neoformans | enzyme of sterol, ergosterol, biosynthesis, enzyme catalyzes last step in demethylation at C-4 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cryptococcus neoformans | - |
var. neoformans, B42419, ATCC 32265, pathogenic fungus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | NADPH-dependent 3-ketosteroid reductase catalyzes reduction of the 3-keto group to a 3beta-hydroxyl group | Cryptococcus neoformans | ? | - |
? | |
additional information | enzyme of sterol, ergosterol, biosynthesis, enzyme catalyzes last step in demethylation at C-4 | Cryptococcus neoformans | ? | - |
? | |
obtusifolione + NADPH | 4,14-dimethyl-ergosta-8,24(28)-dien-3-one | Cryptococcus neoformans | obtusifoliol + NADP+ | 4,14-dimethyl-ergosta-8,24(28)-dien-3-ol | ? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | NADPH-dependent | Cryptococcus neoformans |