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Literature summary for 1.1.1.27 extracted from
- L-Lactate dehydrogenase from leaves of higher plants. Kinetics and regulation of the enzyme from lettuce (Lactuca sativa L) (1981), Biochem. J., 195, 615-622.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-phosphoglycerate | - |
Lactuca sativa |  |
| ADP | - |
Lactuca sativa | |
| Ala | - |
Lactuca sativa | |
| AMP | - |
Lactuca sativa | |
| ATP | competitive with respect to NADH at pH 7.0 and at pH 6.2 | Lactuca sativa | |
| citrate | - |
Lactuca sativa | |
| fructose 1,6-diphosphate | - |
Lactuca sativa | |
| glucose 6-phosphate | - |
Lactuca sativa | |
| Gly | - |
Lactuca sativa | |
| isocitrate | - |
Lactuca sativa | |
| oxalate | - |
Lactuca sativa | |
| Ser | - |
Lactuca sativa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.35 | - |
pyruvate | pH 6.2 | Lactuca sativa | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Lactuca sativa | the enzyme is a component of the system regulating the cellular pH and/or controlling the concentration of reducing equivalents in the cytoplasm of leaf cells | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Lactuca sativa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Lactuca sativa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leaf | - |
Lactuca sativa | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Lactuca sativa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-lactate + NAD+ | - |
Lactuca sativa | pyruvate + NADH + H+ | - |
r | |
| glyoxylate + NADH | - |
Lactuca sativa | glycolate + NAD+ | - |
? | |
| hydroxypyruvate + NADPH + H+ | - |
Lactuca sativa | 2,3-dihydroxypropanoate + NADP+ | - |
? | |
| additional information | the enzyme is a component of the system regulating the cellular pH and/or controlling the concentration of reducing equivalents in the cytoplasm of leaf cells | Lactuca sativa | ? | - |
? | |
| pyruvate + NADH + H+ | - |
Lactuca sativa | (S)-lactate + NAD+ | - |
r | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | coenzyme | Lactuca sativa | |
| NADH | coenzyme | Lactuca sativa | |
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