Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.267 extracted from

  • Wong, A.; Munos, J.W.; Devasthali, V.; Johnson, K.A.; Liu, H.W.
    Study of 1-deoxy-D-xylulose-5-phosphate reductoisomerase: synthesis and evaluation of fluorinated substrate analogues (2004), Org. Lett., 6, 3625-3628.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3-fluoro-1-deoxy-D-xylulose-5-phosphate noncompetitive Escherichia coli
4-fluoro-1-deoxy-D-xylulose-5-phosphate noncompetitive Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.061
-
1-deoxy-D-xylulose-5-phosphate
-
Escherichia coli
0.1
-
1-fluoro-1-deoxy-D-xylulose-5-phosphate
-
Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-deoxy-D-xylulose-5-phosphate + NADPH
-
Escherichia coli methyl-D-erythritol-4-phosphate + NADP+
-
?
1-fluoro-1-deoxy-D-xylulose-5-phosphate + NADPH
-
Escherichia coli ? + NADP+
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.444
-
3-fluoro-1-deoxy-D-xylulose-5-phosphate
-
Escherichia coli
0.733
-
4-fluoro-1-deoxy-D-xylulose-5-phosphate
-
Escherichia coli