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Literature summary for 1.1.1.252 extracted from

  • Brunskole, M.; Stefane, B.; Zorko, K.; Anderluh, M.; Stojan, J.; Lanisnik Rizner, T.; Gobec, S.
    Towards the first inhibitors of trihydroxynaphthalene reductase from Curvularia lunata: Synthesis of artificial substrate, homology modelling and initial screening (2008), Bioorg. Med. Chem., 16, 5881-5889.
    View publication on PubMed

Application

Application Comment Organism
drug development the enzyme represents a target for the development of fungicides and antimicotics Curvularia lunata

Cloned(Commentary)

Cloned (Comment) Organism
GST-tagged enzyme expression in Escherichia coli Curvularia lunata

Inhibitors

Inhibitors Comment Organism Structure
1H-indene-1,3(2H)-dione
-
Curvularia lunata
2,3-Dihydro-2,5-dihydroxy-4H-benzopyran-4-one DDBO, an artificial substrate, chemical synthesis method development, overview Curvularia lunata
diclofenac
-
Curvularia lunata
ethyl 6-methyl-4-oxo-4H-chromene-2-carboxylate
-
Curvularia lunata
ethyl 6-methyl-8-nitro-4-oxo-4H-chromene-2-carboxylate
-
Curvularia lunata
etodolac
-
Curvularia lunata
nabumetone
-
Curvularia lunata

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1,3,8-trihydroxynaphthalene + NADPH + H+ Curvularia lunata the enzyme is an essential enzyme in the biosynthesis of fungal melanin vermelone + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Curvularia lunata
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant GST-tagged enzyme from Escherichia coli by glutathione affinity chromatography Curvularia lunata

Reaction

Reaction Comment Organism Reaction ID
scytalone + NADP+ = 1,3,6,8-tetrahydroxynaphthalene + NADPH + H+ the catalytic triad is formed by residues S149, Y163, and K167 Curvularia lunata

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,3,8-trihydroxynaphthalene + NADPH + H+
-
Curvularia lunata vermelone + NADP+
-
?
1,3,8-trihydroxynaphthalene + NADPH + H+ the enzyme is an essential enzyme in the biosynthesis of fungal melanin Curvularia lunata vermelone + NADP+
-
?

Subunits

Subunits Comment Organism
More enzyme homology modelling, overview Curvularia lunata

Synonyms

Synonyms Comment Organism
3HNR
-
Curvularia lunata
trihydroxynaphthalene reductase
-
Curvularia lunata

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Curvularia lunata

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Curvularia lunata

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.017
-
1H-indene-1,3(2H)-dione pH 7.0 Curvularia lunata
0.017
-
etodolac pH 7.0 Curvularia lunata
0.108
-
diclofenac pH 7.0 Curvularia lunata
0.108
-
ethyl 6-methyl-4-oxo-4H-chromene-2-carboxylate pH 7.0 Curvularia lunata
0.111
-
nabumetone pH 7.0 Curvularia lunata
0.111
-
ethyl 6-methyl-8-nitro-4-oxo-4H-chromene-2-carboxylate pH 7.0 Curvularia lunata