Application | Comment | Organism |
---|---|---|
drug development | the enzyme represents a target for the development of fungicides and antimicotics | Curvularia lunata |
Cloned (Comment) | Organism |
---|---|
GST-tagged enzyme expression in Escherichia coli | Curvularia lunata |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1H-indene-1,3(2H)-dione | - |
Curvularia lunata | |
2,3-Dihydro-2,5-dihydroxy-4H-benzopyran-4-one | DDBO, an artificial substrate, chemical synthesis method development, overview | Curvularia lunata | |
diclofenac | - |
Curvularia lunata | |
ethyl 6-methyl-4-oxo-4H-chromene-2-carboxylate | - |
Curvularia lunata | |
ethyl 6-methyl-8-nitro-4-oxo-4H-chromene-2-carboxylate | - |
Curvularia lunata | |
etodolac | - |
Curvularia lunata | |
nabumetone | - |
Curvularia lunata |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,3,8-trihydroxynaphthalene + NADPH + H+ | Curvularia lunata | the enzyme is an essential enzyme in the biosynthesis of fungal melanin | vermelone + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Curvularia lunata | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant GST-tagged enzyme from Escherichia coli by glutathione affinity chromatography | Curvularia lunata |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
scytalone + NADP+ = 1,3,6,8-tetrahydroxynaphthalene + NADPH + H+ | the catalytic triad is formed by residues S149, Y163, and K167 | Curvularia lunata |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,3,8-trihydroxynaphthalene + NADPH + H+ | - |
Curvularia lunata | vermelone + NADP+ | - |
? | |
1,3,8-trihydroxynaphthalene + NADPH + H+ | the enzyme is an essential enzyme in the biosynthesis of fungal melanin | Curvularia lunata | vermelone + NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | enzyme homology modelling, overview | Curvularia lunata |
Synonyms | Comment | Organism |
---|---|---|
3HNR | - |
Curvularia lunata |
trihydroxynaphthalene reductase | - |
Curvularia lunata |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Curvularia lunata |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Curvularia lunata |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.017 | - |
1H-indene-1,3(2H)-dione | pH 7.0 | Curvularia lunata | |
0.017 | - |
etodolac | pH 7.0 | Curvularia lunata | |
0.108 | - |
diclofenac | pH 7.0 | Curvularia lunata | |
0.108 | - |
ethyl 6-methyl-4-oxo-4H-chromene-2-carboxylate | pH 7.0 | Curvularia lunata | |
0.111 | - |
nabumetone | pH 7.0 | Curvularia lunata | |
0.111 | - |
ethyl 6-methyl-8-nitro-4-oxo-4H-chromene-2-carboxylate | pH 7.0 | Curvularia lunata |