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Literature summary for 1.1.1.236 extracted from

  • Brock, A.; Brandt, W.; Draeger, B.
    The functional divergence of short-chain dehydrogenases involved in tropinone reduction (2008), Plant J., 54, 388-401.
    View publication on PubMed
Search for more literature for 1.1.1.236

Cloned(Commentary)

Cloned (Comment) Organism
gene tr, DNA and amino acid sequence determination and analysis, sequence comparison Cochlearia officinalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Cochlearia officinalis the bifunctional enzyme of Cochlearia officinalis is not stereospecific, in contrast to the Solanaceae species, and catalyzes both tropinone reductase reactions, a tyrosine residue in the active site of Cochlearia officinalis TR is responsible for binding and orientation of tropinone, overview ?
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 ?
tropinone + NADPH + H+ Cochlearia officinalis reaction of tropinone reductase II, EC 1.1.1.236, tropane alkaloid biosynthesis, overview pseudotropine + NADP+ leading to formation of calystegines ?

Organism

Organism UniProt Comment Textmining
Cochlearia officinalis A7DY56
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the bifunctional enzyme of Cochlearia officinalis is not stereospecific, in contrast to the Solanaceae species, and catalyzes both tropinone reductase reactions, a tyrosine residue in the active site of Cochlearia officinalis TR is responsible for binding and orientation of tropinone, overview Cochlearia officinalis ?
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 ?
additional information the enzyme shows broad substrate specificity, several synthetic ketones are accepted as substrates, with higher affinity and faster enzymatic turnover than observed for tropinone, overview Cochlearia officinalis ?
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 ?
tropinone + NADPH + H+ reaction of tropinone reductase II, EC 1.1.1.236, tropane alkaloid biosynthesis, overview Cochlearia officinalis pseudotropine + NADP+ leading to formation of calystegines ?
tropinone + NADPH + H+ reaction of tropinone reductase II, EC 1.1.1.236 Cochlearia officinalis pseudotropine + NADP+
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 ?

Subunits

Subunits Comment Organism
More structure modelling and sequence comparison, overview Cochlearia officinalis

Synonyms

Synonyms Comment Organism
More cf. EC 1.1.1.206, the enzyme is a member of the short-chain dehydrogenase enzyme family Cochlearia officinalis