Inhibitors | Comment | Organism | Structure |
---|---|---|---|
HgCl2 | 0.5 mM, 100% inhibition, 0.05 mM 79% inhibition | Escherichia coli | |
Urea | 2.2 mM, 50% inhibition, reversible | Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.57 | - |
NAD+ | - |
Escherichia coli |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | 0.5 mM, 165% increase | Escherichia coli | |
Zn2+ | 0.5 mM, 20% increase | Escherichia coli |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
52000 | - |
alpha,alpha, 2 * 52000, SDS-PAGE | Escherichia coli |
91000 | - |
gel filtration | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-histidinal + NAD+ + H2O | Escherichia coli | reaction intermediate | L-histidine + NADH + H+ | - |
? | |
L-histidinol + 2 NAD+ + H2O | Escherichia coli | - |
L-histidine + 2 NADH + 2 H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Purification (Comment) | Organism |
---|---|
60°C, pH 5 treatment, ammonium sulfate precipitation, gel filtration, DEAE-cellulose, gel filtration | Escherichia coli |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
15.32 | - |
- |
Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-histidinal + NAD+ + H2O | - |
Escherichia coli | L-histidine + NADH + H+ | - |
? | |
L-histidinal + NAD+ + H2O | reaction intermediate | Escherichia coli | L-histidine + NADH + H+ | - |
? | |
L-histidinol + 2 NAD+ + H2O | - |
Escherichia coli | L-histidine + 2 NADH + 2 H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | alpha,alpha, 2 * 52000, SDS-PAGE | Escherichia coli |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
65 | - |
almost no loss of activity after 5 min at pH 7.5, histidinol, 2 mM and MnCl2, 1 mM, protect enzyme from heat inactivation | Escherichia coli |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9.5 | - |
- |
Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Escherichia coli |