Cloned (Comment) | Organism |
---|---|
overexpression of the enzyme from Xenopus laevis in human smooth muscle cells increases the accumulation of hyaluronan | Xenopus laevis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.3 | - |
NAD+ | - |
Xenopus laevis | |
0.9 | - |
UDP-glucose | - |
Xenopus laevis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucose + 2 NAD+ + H2O | Xenopus laevis | the enzyme has a crucial role during development of Xenopus laevis. Silencing of UGDH decreases glycosaminoglycan synthesis causing severe embryonic malformations because of defective gastrulation process | UDP-glucuronate + 2 NADH + 2 H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Xenopus laevis | Q56R95 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant enzyme | Xenopus laevis |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | silencing of UGDH decreases glycosaminoglycan synthesis causing severe embryonic malformations because of defective gastrulation process. Overexpression of the enzyme from Xenopus laevis in human smooth muscle cells increases the accumulation of hyaluronan | Xenopus laevis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucose + 2 NAD+ + H2O | - |
Xenopus laevis | UDP-glucuronate + 2 NADH + 2 H+ | - |
? | |
UDP-glucose + 2 NAD+ + H2O | the enzyme has a crucial role during development of Xenopus laevis. Silencing of UGDH decreases glycosaminoglycan synthesis causing severe embryonic malformations because of defective gastrulation process | Xenopus laevis | UDP-glucuronate + 2 NADH + 2 H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UGDH | - |
Xenopus laevis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Xenopus laevis |