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Literature summary for 1.1.1.22 extracted from

  • Huh, J.W.; Yoon, H.Y.; Lee, H.J.; Choi, W.B.; Yang, S.J.; Cho, S.W.
    Importance of Gly-13 for the coenzyme binding of human UDP-glucose dehydrogenase (2004), J. Biol. Chem., 279, 37491-37498.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
G13E normal expression and stability of mutant, no enzymic activity, no photoaffinity labeling with nicotinamide 2-azidoadenosine dinucleotide Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.017
-
UDP-glucose pH 8.7, 25°C Homo sapiens
0.133
-
NAD+ pH 8.7, 25°C Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
57000
-
6 * 57000, SDS-PAGE Homo sapiens
340000
-
gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O60701 chemically synthesized gene expressed in Escherichia coli
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucose + 2 NAD+ + H2O
-
Homo sapiens UDP-glucuronate + 2 NADH + 2 H+
-
?

Subunits

Subunits Comment Organism
hexamer 6 * 57000, SDS-PAGE Homo sapiens
More identification of amino acids I7 through T19 as NAD+ binding-site by photoaffinity labeling with nicotinamide 2-azidoadenosine dinucleotide Homo sapiens

Synonyms

Synonyms Comment Organism
UGDH
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens