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Literature summary for 1.1.1.22 extracted from
- Purification and kinetic properties of UDP-glucose dehydrogenase from sugarcane (2002), Arch. Biochem. Biophys., 407, 209-216.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| UDP-glucuronate | competitive | Saccharum spp. |  |
| UDP-xylose | competitive | Saccharum spp. | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0187 | - |
UDP-glucose | pH 8.4, 25°C | Saccharum spp. | |
| 0.0722 | - |
NAD+ | pH 8.4, 25°C | Saccharum spp. | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 52000 | - |
x * 52000, SDS-PAGE | Saccharum spp. |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharum spp. | - |
hybrid | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Saccharum spp. |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| UDP-alpha-D-glucose + 2 NAD+ + H2O = UDP-alpha-D-glucuronate + 2 NADH + 2 H+ | bi-uni-uni-bi mechanism | Saccharum spp. |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| stem | - |
Saccharum spp. | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 2.17 | - |
pH 8.4, 25°C | Saccharum spp. |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP-glucose + NAD+ | 8% of activity with UDP-glucose | Saccharum spp. | CTP-glucuronate + NADH | - |
ir | |
| additional information | no substrate: ADP-glucose | Saccharum spp. | ? | - |
? | |
| TDP-glucose + NAD+ | 2% of activity with UDP-glucose | Saccharum spp. | TDP-glucuronate + NADH | - |
ir | |
| UDP-glucose + 2 NAD+ + H2O | - |
Saccharum spp. | UDP-glucuronate + 2 NADH + 2 H+ | - |
ir | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 52000, SDS-PAGE | Saccharum spp. |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.4 | - |
- |
Saccharum spp. |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Saccharum spp. | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.017 | - |
UDP-xylose | pH 8.4, 25°C | Saccharum spp. | |
| 0.292 | - |
UDP-glucuronate | pH 8.4, 25°C | Saccharum spp. | |
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