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Literature summary for 1.1.1.22 extracted from
- Biosynthesis of uridine diphosphate D-xylose. 3. Uridine diphosphate D-glucose dehydrogenase of Cryptococcus laurentii (1966), Biochemistry, 5, 1864-1869.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Thionicotinamide adenine dinucleotide | can replace NAD+ | Papiliotrema laurentii |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ADP | - |
Papiliotrema laurentii | |
| AMP | - |
Papiliotrema laurentii | |
| UDParabinose | - |
Papiliotrema laurentii | |
| UDPxylose | - |
Papiliotrema laurentii | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Papiliotrema laurentii |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDPglucose + NAD+ + H2O | Papiliotrema laurentii | - |
UDPglucuronate + NADH | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Papiliotrema laurentii | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Papiliotrema laurentii |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
14.0, 1 unit is defined as the amount of enzyme required to produce 0.0002 mM of NADH per min at 30°C | Papiliotrema laurentii |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | no reaction with ethylnicotinate adenine dinucleotide | Papiliotrema laurentii | ? | - |
? | |
| additional information | cosubstrates which can replace NAD+: 3-acetylpyridine adenine dinucleotide | Papiliotrema laurentii | ? | - |
? | |
| additional information | no reaction with alpha-NAD+ | Papiliotrema laurentii | ? | - |
? | |
| additional information | no reaction with 3-formylpyridine adenine dinucleotide | Papiliotrema laurentii | ? | - |
? | |
| additional information | thionicotinamide adenine dinucleotide | Papiliotrema laurentii | ? | - |
? | |
| additional information | no reaction with deamino-NAD+ | Papiliotrema laurentii | ? | - |
? | |
| additional information | no reaction with 3-propionylpyridine adenine dinucleotide | Papiliotrema laurentii | ? | - |
? | |
| UDP-glucose + 2 NAD+ + H2O | - |
Papiliotrema laurentii | UDP-glucuronate + 2 NADH + 2 H+ | - |
? | |
| UDP-glucose + 3-acetylpyridine adenine dinucleotide + H2O | - |
Papiliotrema laurentii | UDP-glucuronate + ? | - |
? | |
| UDP-glucose + thionicotinamide adenine dinucleotide + H2O | - |
Papiliotrema laurentii | UDP-glucuronate + ? | - |
? | |
| UDPglucose + NAD+ + H2O | - |
Papiliotrema laurentii | UDPglucuronate + NADH | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.3 | 7.8 | - |
Papiliotrema laurentii |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.3 | 8.6 | at pH 6.3 and 8.6 about 50% of activity maximum | Papiliotrema laurentii |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| 3-acetylpyridine adenine dinucleotide | can replace NAD+ | Papiliotrema laurentii | |
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Release 2023.1 (January 2023)
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