Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence analysis and comparison | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | an androgen-inactivating enzyme, important in androgen and progesterone metabolism | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | same expression level in female and male livers | Mus musculus | - |
additional information | the androgen-inactivating enzyme is selectively expressed in female tissue, while it is mostly absent in male tissue, tissue distribution, overview | Mus musculus | - |
pituitary gland | 6fold higher expression level in female than in male pituitary | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-androstanedione + NADPH + H+ | - |
Mus musculus | 5alpha-androstan-3alpha-ol-17-one + NADP+ | i.e. allopregnanolone | ? | |
5alpha-dihydrotestosterone + NADPH | i.e. DHT | Mus musculus | 5alpha-androstane-3alpha,17beta-diol + NADP+ | - |
? | |
dihydroprogesterone + NADPH | - |
Mus musculus | androsterone + NADP+ | - |
? | |
additional information | an androgen-inactivating enzyme, important in androgen and progesterone metabolism | Mus musculus | ? | - |
? | |
additional information | the enzyme might play an important role in female physiology, substrate specificity, overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3alpha-hydroxysteroid dehydrogenase | - |
Mus musculus |