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Literature summary for 1.1.1.211 extracted from
- Human liver long-chain 3-hydroxyacyl-coenzyme A dehydrogenase is a multifunctional membrane-bound beta-oxidation enzyme of mitochondria (1992), Biochem. Biophys. Res. Commun., 183, 443 - 448.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 47000 | - |
alpha2,beta2, 1 * 71000 + 1 * 47000, SDS-PAGE | Homo sapiens |
| 71000 | - |
alpha2,beta2, 1 * 71000 + 1 * 47000, SDS-PAGE | Homo sapiens |
| 230000 | - |
liver, gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | trifunctional, membrane bound, beta-oxidation enzyme | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
no activity with acetoacetyl-CoA | Homo sapiens |
| 3.2 | 7.4 | 3-hydroxyoctanoyl-CoA oxidation | Homo sapiens |
| 15 | 35 | 3-ketohexadecanoyl-CoA reduction | Homo sapiens |
| 16.3 | - |
3-ketohexadecanoyl-CoA reduction | Homo sapiens |
| 30.4 | - |
3-ketohexadecanoyl-CoA reduction | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-hydroxyoctanoyl-CoA + NAD+ | - |
Homo sapiens | 3-ketooctanoyl-CoA + NADH | - |
? | |
| 3-ketohexadecanoyl-CoA + NADH | - |
Homo sapiens | 3-hydroxyhexadecanoyl-CoA + NAD+ | - |
? | |
| 3-ketohexanoyl-CoA + NADH | - |
Homo sapiens | 3-hydroxyhexanoyl-CoA + NAD+ | - |
? | |
| 3-oxodecanoyl-CoA + NADH | - |
Homo sapiens | 3-hydroxydecanoyl-CoA + NAD+ | - |
? | |
| additional information | trifunctional, membrane bound, beta-oxidation enzyme | Homo sapiens | ? | - |
? | |
| additional information | has also enoyl-CoA-hydratase activity | Homo sapiens | additional information | has also 3-ketoacyl-CoA thiolase activity | ? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | alpha2,beta2, 1 * 71000 + 1 * 47000, SDS-PAGE | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Homo sapiens | |
| NADH | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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