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Literature summary for 1.1.1.21 extracted from

  • Celestina, S.K.; Sundaram, K.; Ravi, S.
    Novel derivatives of rhodanine-3-hippuric acid as active inhibitors of aldose reductase synthesis, biological evaluation, and molecular docking analysis (2019), Russ. J. Bioorg. Chem., 45, 405-415 .
No PubMed abstract available
Search for more literature for 1.1.1.21

Crystallization (Commentary)

Crystallization (Comment) Organism
docking studies of rhodanine-3-hippuric acid and its benzylidene derivatives Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
2-(4-((Z)-5-(2,3-dichlorobenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido) acetic acid
-
 Rattus norvegicus
2-(4-((Z)-5-(2-bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
-
 Rattus norvegicus
2-(4-((Z)-5-(2-chlorobenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido)aceticacid
-
 Rattus norvegicus
2-(4-((Z)-5-(2-fluorobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
-
 Rattus norvegicus
2-(4-((Z)-5-(2-methoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
-
 Rattus norvegicus
2-(4-((Z)-5-(2-methylbenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
-
 Rattus norvegicus
2-(4-((Z)-5-(2-nitrobenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
-
 Rattus norvegicus
2-(4-((Z)-5-(3,4,5-trimethoxybenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido) acetic acid
-
 Rattus norvegicus
2-(4-((Z)-5-(3-bromobenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
-
 Rattus norvegicus
2-(4-((Z)-5-(3-chlorobenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
-
 Rattus norvegicus
2-(4-((Z)-5-(3-fluorobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
-
 Rattus norvegicus
2-(4-((Z)-5-(3-methoxybenzylidene)-4-oxo-2-thioxothiazolidin-3yl)benzamido)acetic acid
-
 Rattus norvegicus
2-(4-((Z)-5-(3-methylbenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
-
 Rattus norvegicus
2-(4-((Z)-5-(3-nitrobenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
-
 Rattus norvegicus
2-(4-((Z)-5-(4-bromobenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
-
 Rattus norvegicus
2-(4-((Z)-5-(4-chlorobenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
-
 Rattus norvegicus
2-(4-((Z)-5-(4-fluorobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
-
 Rattus norvegicus
2-(4-((Z)-5-(4-formylbenzylidene) 4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
-
 Rattus norvegicus
2-(4-((Z)-5-(4-methoxybenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
-
 Rattus norvegicus
2-(4-((Z)-5-(4-methylbenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
-
 Rattus norvegicus
2-(4-((Z)-5-(4-nitrobenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
-
 Rattus norvegicus
2-(4-((Z)-5-benzylidene-4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
-
 Rattus norvegicus
2-(4-(4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid i.e. rhodanine-3-hippuric acid Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Rattus norvegicus
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0002
-
 pH 6.2, 37°C Rattus norvegicus 2-(4-((Z)-5-(3-fluorobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
0.0006
-
 pH 6.2, 37°C Rattus norvegicus 2-(4-((Z)-5-(3,4,5-trimethoxybenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido) acetic acid
0.00118
-
 pH 6.2, 37°C Rattus norvegicus 2-(4-((Z)-5-(3-methoxybenzylidene)-4-oxo-2-thioxothiazolidin-3yl)benzamido)acetic acid
0.0012
-
 pH 6.2, 37°C Rattus norvegicus 2-(4-((Z)-5-(4-nitrobenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
0.00127
-
 pH 6.2, 37°C Rattus norvegicus 2-(4-((Z)-5-(2,3-dichlorobenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido) acetic acid
0.0013
-
 pH 6.2, 37°C Rattus norvegicus 2-(4-((Z)-5-(4-methoxybenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
0.00146
-
 pH 6.2, 37°C Rattus norvegicus 2-(4-((Z)-5-(3-bromobenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
0.00148
-
 pH 6.2, 37°C Rattus norvegicus 2-(4-((Z)-5-(2-methoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
0.0015
-
 pH 6.2, 37°C Rattus norvegicus 2-(4-((Z)-5-(4-bromobenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
0.00152
-
 pH 6.2, 37°C Rattus norvegicus 2-(4-(4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
0.0016
-
 pH 6.2, 37°C Rattus norvegicus 2-(4-((Z)-5-benzylidene-4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
0.00161
-
 pH 6.2, 37°C Rattus norvegicus 2-(4-((Z)-5-(3-nitrobenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
0.00162
-
 pH 6.2, 37°C Rattus norvegicus 2-(4-((Z)-5-(3-methylbenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
0.00164
-
 pH 6.2, 37°C Rattus norvegicus 2-(4-((Z)-5-(3-chlorobenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
0.00169
-
 pH 6.2, 37°C Rattus norvegicus 2-(4-((Z)-5-(2-nitrobenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
0.0018
-
 pH 6.2, 37°C Rattus norvegicus 2-(4-((Z)-5-(4-chlorobenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
0.00187
-
 pH 6.2, 37°C Rattus norvegicus 2-(4-((Z)-5-(4-fluorobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
0.002
-
 pH 6.2, 37°C Rattus norvegicus 2-(4-((Z)-5-(2-bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
0.002
-
 pH 6.2, 37°C Rattus norvegicus 2-(4-((Z)-5-(2-chlorobenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido)aceticacid
0.00212
-
 pH 6.2, 37°C Rattus norvegicus 2-(4-((Z)-5-(2-fluorobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
0.00215
-
 pH 6.2, 37°C Rattus norvegicus 2-(4-((Z)-5-(4-methylbenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
0.00234
-
 pH 6.2, 37°C Rattus norvegicus 2-(4-((Z)-5-(4-formylbenzylidene) 4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid
0.00236
-
 pH 6.2, 37°C Rattus norvegicus 2-(4-((Z)-5-(2-methylbenzylidene)4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid