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Literature summary for 1.1.1.21 extracted from

  • Alim, Z.; Kilinc, N.; Sengul, B.; Beydemir, S.
    Mechanism of capsaicin inhibition of aldose reductase activity (2017), J. Biochem. Mol. Toxicol., 31, e21898 .
    View publication on PubMed
Search for more literature for 1.1.1.21

Inhibitors

Inhibitors Comment Organism Structure
capsaicin noncompetitive Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
heart
-
 Rattus norvegicus
-
kidney
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0089
-
 capsaicin enzyme isolated from heart, pH 6.2, temperature not specified in the publication Rattus norvegicus
0.267
-
 capsaicin enzyme isolated from kidney, pH 6.2, temperature not specified in the publication Rattus norvegicus
0.535
-
 capsaicin enzyme isolated from liver, pH 6.2, temperature not specified in the publication Rattus norvegicus
0.597
-
 capsaicin enzyme isolated from brain, pH 6.2, temperature not specified in the publication Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0075
-
 enzyme isolated from heart, pH 6.2, temperature not specified in the publication Rattus norvegicus capsaicin
0.367
-
 enzyme isolated from kidney, pH 6.2, temperature not specified in the publication Rattus norvegicus capsaicin
0.734
-
 enzyme isolated from liver, pH 6.2, temperature not specified in the publication Rattus norvegicus capsaicin
0.904
-
 enzyme isolated from brain, pH 6.2, temperature not specified in the publication Rattus norvegicus capsaicin