Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetic acid | 7fold selectivity for ALR2 over ALR1 | Homo sapiens | |
(2-oxo-8-phenyl-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetic acid | - |
Homo sapiens | |
(2-oxo-8-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetic acid | 24fold selectivity for ALR2 over ALR1 | Homo sapiens | |
epalrestat | 26.7fold selectivity for ALR2 over ALR1 | Homo sapiens | |
additional information | use of dihydrobenzoxazinone derivatives as aldose reductase inhibitors. Most of the derivatives with styryl side chains exhibit good inhibitory activities and most of the compounds reveal powerful antioxidant activity | Homo sapiens | |
[2-oxo-8-[(E)-2-phenylethenyl]-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetic acid | 9fold selectivity for ALR2 over ALR1 | Homo sapiens | |
[8-(4-formylphenyl)-2-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetic acid | - |
Homo sapiens | |
[8-(4-methoxyphenyl)-2-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetic acid | - |
Homo sapiens | |
[8-[(E)-2-(4-fluorophenyl)ethenyl]-2-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetic acid | 25.7fold selectivity for ALR2 over ALR1 | Homo sapiens | |
[8-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]-2-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetic acid | 24fold selectivity for ALR2 over ALR1 | Homo sapiens | |
[8-[(E)-2-(4-hydroxyphenyl)ethenyl]-2-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetic acid | 60fold selectivity for ALR2 over ALR1 | Homo sapiens | |
[8-[(E)-2-(4-methoxyphenyl)ethenyl]-2-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetic acid | - |
Homo sapiens | |
[8-[(E)-2-(4-methylphenyl)ethenyl]-2-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetic acid | - |
Homo sapiens | |
[8-[(E)-2-(4-nitrophenyl)ethenyl]-2-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetic acid | - |
Homo sapiens | |
[8-[(E)-2-(4-tert-butylphenyl)ethenyl]-2-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetic acid | 4fold selectivity for ALR2 over ALR1 | Homo sapiens | |
[8-[(E)-2-([1,1'-biphenyl]-4-yl)ethenyl]-2-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetic acid | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P15121 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
ALR2 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000045 | - |
pH 6.2, 30°C | Homo sapiens | epalrestat | |
0.000082 | - |
30°C, pH 6.2 | Homo sapiens | [8-[(E)-2-(4-hydroxyphenyl)ethenyl]-2-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetic acid | |
0.000138 | - |
30°C, pH 6.2 | Homo sapiens | (2-oxo-8-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetic acid | |
0.000167 | - |
30°C, pH 6.2 | Homo sapiens | [8-[(E)-2-(4-fluorophenyl)ethenyl]-2-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetic acid | |
0.00017 | - |
30°C, pH 6.2 | Homo sapiens | [8-[(E)-2-(4-tert-butylphenyl)ethenyl]-2-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetic acid | |
0.000188 | - |
30°C, pH 6.2 | Homo sapiens | [8-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]-2-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetic acid | |
0.000208 | - |
30°C, pH 6.2 | Homo sapiens | [8-[(E)-2-(4-methoxyphenyl)ethenyl]-2-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetic acid | |
0.00022 | - |
30°C, pH 6.2 | Homo sapiens | [8-[(E)-2-(4-methylphenyl)ethenyl]-2-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetic acid | |
0.000262 | - |
30°C, pH 6.2 | Homo sapiens | [8-[(E)-2-(4-nitrophenyl)ethenyl]-2-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetic acid | |
0.000281 | - |
30°C, pH 6.2 | Homo sapiens | [8-[(E)-2-([1,1'-biphenyl]-4-yl)ethenyl]-2-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetic acid | |
0.000308 | - |
30°C, pH 6.2 | Homo sapiens | [2-oxo-8-[(E)-2-phenylethenyl]-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetic acid | |
0.000774 | - |
30°C, pH 6.2 | Homo sapiens | [8-(4-methoxyphenyl)-2-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetic acid | |
0.00105 | - |
30°C, pH 6.2 | Homo sapiens | [8-(4-formylphenyl)-2-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetic acid | |
0.001932 | - |
30°C, pH 6.2 | Homo sapiens | (2-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetic acid | |
0.00334 | - |
30°C, pH 6.2 | Homo sapiens | (2-oxo-8-phenyl-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetic acid |