Crystallization (Comment) | Organism |
---|---|
molecular docking of inhibitors | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1'-(4-fluorobenzene-1-sulfonyl)spiro[fluorene-9,4'-imidazolidine]-2',5'-dione | no selectivity for ALR2 over ALR1 | Homo sapiens | |
1'-(5-chlorothiophene-2-sulfonyl)spiro[fluorene-9,4'-imidazolidine]-2',5'-dione | 3.4fold selectivity for ALR2 over ALR1 | Homo sapiens | |
1-(4-fluorophenyl)-1,3-diazaspiro[4.5]decane-2,4-dione | 2.1fold selectivity for ALR2 over ALR1 | Homo sapiens | |
1-(4-methoxyphenyl)-1,3-diazaspiro[4.5]decane-2,4-dione | 8.5fold selectivity for ALR2 over ALR1 | Homo sapiens | |
1-(4-methylphenyl)-1,3-diazaspiro[4.5]decane-2,4-dione | 1.5fold selectivity for ALR2 over ALR1 | Homo sapiens | |
1-(5-chlorothiophen-2-yl)-1,3-diazaspiro[4.5]decane-2,4-dione | 1.9fold selectivity for ALR2 over ALR1 | Homo sapiens | |
3'-(4-fluorobenzene-1-sulfonyl)spiro[fluorene-9,4'-imidazolidine]-2',5'-dione | 10fold selectivity for ALR2 over ALR1 | Homo sapiens | |
3'-(5-chlorothiophene-2-sulfonyl)spiro[fluorene-9,4'-imidazolidine]-2',5'-dione | 1.1fold selectivity for ALR2 over ALR1 | Homo sapiens | |
3-(4-fluorophenyl)-1,3-diazaspiro[4.5]decane-2,4-dione | 2.3fold selectivity for ALR2 over ALR1 | Homo sapiens | |
3-(4-methoxyphenyl)-1,3-diazaspiro[4.5]decane-2,4-dione | 1.2fold selectivity for ALR2 over ALR1 | Homo sapiens | |
3-(4-methylphenyl)-1,3-diazaspiro[4.5]decane-2,4-dione | 11fold selectivity for ALR2 over ALR1 | Homo sapiens | |
3-(5-chlorothiophen-2-yl)-1,3-diazaspiro[4.5]decane-2,4-dione | 127fold selectivity for ALR2 over ALR1, 79% reduction in blood glucose level | Homo sapiens | |
additional information | synthesis of spiroimidazolidine-2,4-dione derivatives which preserve the minimum requirements of the proposed pharmacophoric models to enhance both activities. All compounds (except 1-(4-methoxyphenyl)-1,3-diazaspiro[4.5]decane-2,4-dione) reduce the blood glucose level and all inhibit aldose reductase activity | Homo sapiens | |
sorbinil | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P15121 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
AKR1B1 | - |
Homo sapiens |
ALR2 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00047 | - |
pH 6.2, 33°C | Homo sapiens | 3-(5-chlorothiophen-2-yl)-1,3-diazaspiro[4.5]decane-2,4-dione | |
0.00162 | - |
pH 6.2, 33°C | Homo sapiens | 3'-(4-fluorobenzene-1-sulfonyl)spiro[fluorene-9,4'-imidazolidine]-2',5'-dione | |
0.00253 | - |
pH 6.2, 33°C | Homo sapiens | 1-(4-methoxyphenyl)-1,3-diazaspiro[4.5]decane-2,4-dione | |
0.00353 | - |
pH 6.2, 33°C | Homo sapiens | 3-(4-methylphenyl)-1,3-diazaspiro[4.5]decane-2,4-dione | |
0.00375 | - |
pH 6.2, 33°C | Homo sapiens | 1'-(5-chlorothiophene-2-sulfonyl)spiro[fluorene-9,4'-imidazolidine]-2',5'-dione | |
0.00478 | - |
pH 6.2, 33°C | Homo sapiens | 1-(5-chlorothiophen-2-yl)-1,3-diazaspiro[4.5]decane-2,4-dione | |
0.00491 | - |
pH 6.2, 33°C | Homo sapiens | 3'-(5-chlorothiophene-2-sulfonyl)spiro[fluorene-9,4'-imidazolidine]-2',5'-dione | |
0.00768 | - |
pH 6.2, 33°C | Homo sapiens | 3-(4-fluorophenyl)-1,3-diazaspiro[4.5]decane-2,4-dione | |
0.00776 | - |
pH 6.2, 33°C | Homo sapiens | 1-(4-fluorophenyl)-1,3-diazaspiro[4.5]decane-2,4-dione | |
0.00831 | - |
pH 6.2, 33°C | Homo sapiens | 3-(4-methoxyphenyl)-1,3-diazaspiro[4.5]decane-2,4-dione | |
0.00872 | - |
pH 6.2, 33°C | Homo sapiens | 1-(4-methylphenyl)-1,3-diazaspiro[4.5]decane-2,4-dione | |
0.0111 | - |
pH 6.2, 33°C | Homo sapiens | 1'-(4-fluorobenzene-1-sulfonyl)spiro[fluorene-9,4'-imidazolidine]-2',5'-dione |