Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
aldose + NADPH + H+ | Homo sapiens | - |
alditol + NADP+ | - |
? | |
aldose + NADPH + H+ | Mus musculus | - |
alditol + NADP+ | - |
? | |
additional information | Mus musculus | reduction of carnosine-propanal conjugates in murine tissues, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P15121 | - |
- |
Mus musculus | P45376 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain | - |
Mus musculus | - |
heart | - |
Homo sapiens | - |
heart | - |
Mus musculus | - |
skeletal muscle | - |
Homo sapiens | - |
skeletal muscle | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
aldose + NADPH + H+ | - |
Homo sapiens | alditol + NADP+ | - |
? | |
aldose + NADPH + H+ | - |
Mus musculus | alditol + NADP+ | - |
? | |
additional information | reduction of carnosine-propanal conjugates in murine tissues, overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aldose reductase | - |
Homo sapiens |
aldose reductase | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
recombinant enzyme | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
recombinant enzyme | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens | |
NADPH | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | carnosine-propanals are converted to carnosine-propanols in the lysates of heart, skeletal muscle, and brain tissue from wild-type but not AR-null mice. In comparison with wild-type mice, the urinary excretion of carnosine-propanols is decreased in AR-null mice, overview | Mus musculus |
malfunction | inhibition of AKR1B1 both prevents and reverses diabetic tissue injury that arises from the accumulation of sorbitol | Homo sapiens |
physiological function | increased reduction of glucose to sorbitol under hyperglycemic conditions is implicated in tissue injury and the progression of a wide variety of diabetic complications, including neuropathy and retinopathy | Homo sapiens |
physiological function | lipid peroxidation generates unsaturated aldehydes, such as acrolein, that form conjugates with histidyl dipeptides. Carnosine-aldehyde conjugates form covalent adducts with proteins and are reduced by aldose reductase. Detoxification of carnosine-aldehyde by aldose reductase prevents protein carnosinylation. Aldose reductase prevents tissue injury due to aldehyde-carnosine conjugates. Role of aldose reductase as a critical regulator of protein carnosinylation and carnosine-mediated tissue protection, overview | Homo sapiens |
physiological function | lipid peroxidation generates unsaturated aldehydes, such as acrolein, that form conjugates with histidyl dipeptides.Carnosine-aldehyde conjugates form covalent adducts with proteins and are reduced by aldose reductase. Detoxification of carnosine-aldehyde by aldose reductase prevents protein carnosinylation. Aldose reductase prevents tissue injury due to aldehyde-carnosine conjugates. Carnosine-propanals are converted to carnosine-propanols in the lysates of heart, skeletal muscle, and brain tissue from wild-type but not AR-null mice. Role of aldose reductase as a critical regulator of protein carnosinylation and carnosine-mediated tissue protection, overview | Mus musculus |