Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(4-nitrobenzyl)-3-(4-(2-morpholinoethyl)piperazin-1-yl)quinoxalin-2(1H)-one | - |
Rattus norvegicus | |
1-(4-nitrobenzyl)-3-(4-(4-methoxyphenyl)piperazin-1-yl)quinoxalin-2(1H)-one | - |
Rattus norvegicus | |
1-(4-nitrobenzyl)-3-(4-(pyrazin-2-yl)piperazin-1-yl)quinoxalin-2(1H)-one} | - |
Rattus norvegicus | |
1-(4-nitrobenzyl)-3-styryl-quinoxalin-2(1H)-one | - |
Rattus norvegicus | |
2-(2-oxo-3-phenethylquinoxalin-1(2H)-yl)acetic acid | 22% inhibition | Rattus norvegicus | |
2-(2-oxo-3-styrylquinoxalin-1(2H)-yl)acetic acid | 32% inhibition | Rattus norvegicus | |
2-(3-(2,4-difluorophenylamino)-6-nitro-2-oxoquinoxalin-1(2H)-yl) acetic acid} | 41% inhibition | Rattus norvegicus | |
2-(3-(3-(tert-butylamino)-3-oxoprop-1-en-1-yl)-2-oxoquinoxalin-1(2H)-yl)acetic acid | 25% inhibition | Rattus norvegicus | |
2-(3-(4-(4-methoxyphenyl) piperazin-1-yl)-2-oxoquinoxalin-1(2H)-yl)acetic acid | 48% inhibition | Rattus norvegicus | |
2-(3-(4-fluorophenethyl)-2-oxoquinoxalin-1(2H)-yl)acetic acid | 40% inhibition | Rattus norvegicus | |
2-(3-(4-fluorostyryl)-2-oxoquinoxalin-1(2H)-yl)acetic acid | 47% inhibition | Rattus norvegicus | |
2-(3-(4-fluorostyryl)-6-nitro-2-oxoquinoxalin-1(2H)-yl)acetic acid} | 25% inhibition | Rattus norvegicus | |
2-(6-chloro-3-(4-fluoro-styryl)-2-oxoquinoxalin-1(2H)-yl)acetic acid | 25% inhibition | Rattus norvegicus | |
2-(7-chloro-2-oxo-3-styrylquinoxalin-1(2H)-yl) acetic acid} | 35% inhibition | Rattus norvegicus | |
3-(4-fluorostyryl)-1-(4-nitrobenzyl)quinoxalin-2(1H)-one | - |
Rattus norvegicus | |
3-(benzo[b] thiophen-3-yl)-1-(4-nitrobenzylquinoxalin-2(1H)-one | - |
Rattus norvegicus | |
additional information | structure-activity relationships study of quinoxalinone derivatives as aldose reductase inhibitors. Among them, N1-acetate derivatives have significant activity, molecular modeling and docking, overview. Both C3-phenethyl and C6-NO2 groups play an important role in enhancing the activity and selectivity of the quinoxalinone based inhibitors | Rattus norvegicus | |
N-(tert-butyl)-3-(4-(4-nitrobenzyl)-3-oxo-3,4-dihydroquinoxalin-2-ylacryl amide | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P07943 | - |
- |
Rattus norvegicus Wistar | P07943 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glyceraldehyde + NADPH + H+ | - |
Rattus norvegicus | glycerol + NADP+ | - |
r | |
D-glyceraldehyde + NADPH + H+ | - |
Rattus norvegicus Wistar | glycerol + NADP+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
ALR2 | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at, ALR2 | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.2 | - |
assay at, ALR2 | Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
evolution | aldose reductase (ALR2) is a member of aldo-keto reductase superfamily | Rattus norvegicus |