Application | Comment | Organism |
---|---|---|
drug development | the enzyme may be a potential drug target or vaccine candidate for schistosomes | Schistosoma japonicum |
medicine | the enzyme may be a potential drug target or vaccine candidate for schistosomes | Schistosoma japonicum |
Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence determination and analysis, phylogenetic analysis, RT-PCRexpression analysis, recombinant expressionin Escherichia coli strain BL21 (DE3) | Schistosoma japonicum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
epalrestat | - |
Schistosoma japonicum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Schistosoma japonicum | Q5DD64 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cercaria | - |
Schistosoma japonicum | - |
additional information | the enzyme is expressed at each of the development stages analyzed with increased levels in cercariae, and is expressed at higher levels in adult male worms than in adult female worms, it is mainly distributed in the gynecophoral canal of adult male worms | Schistosoma japonicum | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DL-glyceraldehyde + NADPH | - |
Schistosoma japonicum | glycerol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aldose reductase | - |
Schistosoma japonicum |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Schistosoma japonicum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.2 | - |
assay at | Schistosoma japonicum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Schistosoma japonicum |
General Information | Comment | Organism |
---|---|---|
additional information | recombinant enzyme protein displays a significant level of antigenicity in BALB/c mice | Schistosoma japonicum |