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Literature summary for 1.1.1.21 extracted from

  • Liu, J.; Wang, J.; Wang, S.; Xu, B.; Liu, X.; Wang, X.; Hu, W.
    Molecular cloning and characterization of Schistosoma japonicum aldose reductase (2013), Parasitol. Res., 112, 549-558.
    View publication on PubMed

Application

Application Comment Organism
drug development the enzyme may be a potential drug target or vaccine candidate for schistosomes Schistosoma japonicum
medicine the enzyme may be a potential drug target or vaccine candidate for schistosomes Schistosoma japonicum

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, phylogenetic analysis, RT-PCRexpression analysis, recombinant expressionin Escherichia coli strain BL21 (DE3) Schistosoma japonicum

Inhibitors

Inhibitors Comment Organism Structure
epalrestat
-
Schistosoma japonicum

Organism

Organism UniProt Comment Textmining
Schistosoma japonicum Q5DD64
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cercaria
-
Schistosoma japonicum
-
additional information the enzyme is expressed at each of the development stages analyzed with increased levels in cercariae, and is expressed at higher levels in adult male worms than in adult female worms, it is mainly distributed in the gynecophoral canal of adult male worms Schistosoma japonicum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DL-glyceraldehyde + NADPH
-
Schistosoma japonicum glycerol + NADP+
-
?

Synonyms

Synonyms Comment Organism
aldose reductase
-
Schistosoma japonicum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Schistosoma japonicum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.2
-
assay at Schistosoma japonicum

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Schistosoma japonicum

General Information

General Information Comment Organism
additional information recombinant enzyme protein displays a significant level of antigenicity in BALB/c mice Schistosoma japonicum