Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.21 extracted from

  • Xu, Z.; Yang, H.; Zhou, M.; Feng, Y.; Jia, W.
    Inhibitory effect of total lignan from fructus Arctii on aldose reductase (2010), Phytother. Res., 24, 472-473.
    View publication on PubMed
Search for more literature for 1.1.1.21

Inhibitors

Inhibitors Comment Organism Structure
epalrestat
-
 Rattus norvegicus
additional information inhibitory effect of total lignan from fructus Arctii on aldose reductase, ethanolic extract from dry ripe fruits of Arctium lappa Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DL-glyceraldehyde + NADPH + H+ Rattus norvegicus
-
 DL-glycerol + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
lens
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DL-glyceraldehyde + NADPH + H+
-
 Rattus norvegicus DL-glycerol + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
aldose reductase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.2
-
 assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus

General Information

General Information Comment Organism
metabolism aldose reductase is the key enzyme in the polyol pathway Rattus norvegicus