Inhibitors | Comment | Organism | Structure |
---|---|---|---|
((1-(2H-tetrazol-5-yl)methyl)-1H-pyrrol-3-yl)(phenyl)-methanone | 40% inhibition | Rattus norvegicus | |
(1-(2-(2H-tetrazol-5-yl)ethyl)-1H-pyrrol-3-yl)(phenyl)-methanone | 6% inhibition | Rattus norvegicus | |
(1-(2H-tetrazole-5-yl)-1H-pyrrol-2-yl)(phenyl)-methanone | - |
Rattus norvegicus | |
(1-(2H-tetrazole-5-yl)-1H-pyrrol-3-yl)(phenyl)-methanone | - |
Rattus norvegicus | |
(1-(3-(2H-tetrazol-5-yl)propyl)-1H-pyrrol-3-yl)(phenyl)-methanone | 41% inhibition | Rattus norvegicus | |
2-(3-benzoyl-1H-pyrrol-1-yl)acetic acid | - |
Rattus norvegicus | |
3-(3-benzoyl-1H-pyrrol-1-yl)propanoic acid | - |
Rattus norvegicus | |
4-(3-benzoyl-1H-pyrrol-1-yl)butanoic acid | - |
Rattus norvegicus | |
additional information | design and synthesis of pyrrole based inhibitors and evaluation as selective aldose reductase inhibitors, bioisosterism between a carboxylic acid moiety and that of a tetrazole, overview | Rattus norvegicus | |
sorbinil | - |
Rattus norvegicus | |
Valproic acid | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
ALR2 partially from lenses | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lens | ALR2 | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucuronate + NADPH | - |
Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aldose reductase | - |
Rattus norvegicus |
ALR2 | - |
Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00025 | - |
pH 7.2, temperature not specified in the publication | Rattus norvegicus | sorbinil | |
0.002 | - |
pH 7.2, temperature not specified in the publication | Rattus norvegicus | 2-(3-benzoyl-1H-pyrrol-1-yl)acetic acid | |
0.006 | - |
pH 7.2, temperature not specified in the publication | Rattus norvegicus | 4-(3-benzoyl-1H-pyrrol-1-yl)butanoic acid | |
0.0097 | - |
pH 7.2, temperature not specified in the publication | Rattus norvegicus | 3-(3-benzoyl-1H-pyrrol-1-yl)propanoic acid | |
0.018 | - |
pH 7.2, temperature not specified in the publication | Rattus norvegicus | (1-(2H-tetrazole-5-yl)-1H-pyrrol-3-yl)(phenyl)-methanone | |
0.02 | - |
pH 7.2, temperature not specified in the publication | Rattus norvegicus | (1-(2H-tetrazole-5-yl)-1H-pyrrol-2-yl)(phenyl)-methanone | |
0.0501 | - |
pH 7.2, temperature not specified in the publication | Rattus norvegicus | Valproic acid |