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Literature summary for 1.1.1.21 extracted from

  • Cosconati, S.; Marinelli, L.; La Motta, C.; Sartini, S.; Da Settimo, F.; Olson, A.J.; Novellino, E.
    Pursuing aldose reductase inhibitors through in situ cross-docking and similarity-based virtual screening (2009), J. Med. Chem., 52, 5578-5581.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(2R)-1-[(benzyloxy)carbonyl]-2,3-dihydro-1H-indole-2-carboxylic acid CC-13401 Homo sapiens
([2-[(4-methoxy-1-methyl-1H-indazol-3-yl)amino]-2-oxoethyl]sulfanyl)acetic acid HTS-03834 Homo sapiens
2,1,3-benzoxadiazol-5-yl 5-chlorothiophene-2-sulfonate KM-07100 Homo sapiens
2,2'-[sulfonylbis(benzene-4,1-diyliminomethylylidene)]dipropanedinitrile BTB-06667 Homo sapiens
3,4-dinitro-2,5-bis(phenylsulfanyl)thiophene SEW-05367 Homo sapiens
3-(4-nitrophenyl)-2-[(phenylsulfonyl)amino]propanoic acid SPB-08302 Homo sapiens
3-benzyl-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl 4-methylbenzenesulfonate NRB-05245 Homo sapiens
4-[3-(5-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidin-6-yl)-1,2,4-oxadiazol-5-yl]butanoic acid SB-02066; SEW-01456 Homo sapiens
5-oxo-3-phenyl-5-(quinolin-2-ylamino)pentanoic acid HTS-06058 Homo sapiens
IDD594
-
Homo sapiens
pyrazolo[5,1-c][1,2,4]benzotriazin-8-yl dimethylcarbamate EN-00263 Homo sapiens
sorbinil
-
Homo sapiens
Tolrestat
-
Homo sapiens
[[(4-methylphenyl)sulfonyl](2-thiophen-2-ylethyl)amino]acetic acid S-12728 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P15121
-
-

Synonyms

Synonyms Comment Organism
aldose reductase
-
Homo sapiens
ALR2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00119
-
-
Homo sapiens 4-[3-(5-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidin-6-yl)-1,2,4-oxadiazol-5-yl]butanoic acid
0.00392
-
-
Homo sapiens 4-[3-(5-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidin-6-yl)-1,2,4-oxadiazol-5-yl]butanoic acid
0.03108
-
-
Homo sapiens 3-benzyl-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl 4-methylbenzenesulfonate
0.03561
-
-
Homo sapiens 2,1,3-benzoxadiazol-5-yl 5-chlorothiophene-2-sulfonate
0.0387
-
-
Homo sapiens pyrazolo[5,1-c][1,2,4]benzotriazin-8-yl dimethylcarbamate
0.04141
-
-
Homo sapiens (2R)-1-[(benzyloxy)carbonyl]-2,3-dihydro-1H-indole-2-carboxylic acid
0.05887
-
-
Homo sapiens [[(4-methylphenyl)sulfonyl](2-thiophen-2-ylethyl)amino]acetic acid
0.07764
-
-
Homo sapiens ([2-[(4-methoxy-1-methyl-1H-indazol-3-yl)amino]-2-oxoethyl]sulfanyl)acetic acid
0.0853
-
-
Homo sapiens 5-oxo-3-phenyl-5-(quinolin-2-ylamino)pentanoic acid
0.1073
-
-
Homo sapiens 3-(4-nitrophenyl)-2-[(phenylsulfonyl)amino]propanoic acid
0.4812
-
-
Homo sapiens 3,4-dinitro-2,5-bis(phenylsulfanyl)thiophene
0.5271
-
-
Homo sapiens 2,2'-[sulfonylbis(benzene-4,1-diyliminomethylylidene)]dipropanedinitrile