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Literature summary for 1.1.1.21 extracted from
- From a dull enzyme to something else: facts and perspectives regarding aldose reductase (2008), Curr. Med. Chem., 15, 1452-1461.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | ALR2 is a critical target to prevent and control diabetic complications through the inhibition of its activity | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| aldose + NADPH + H+ | Homo sapiens | - |
alditol + NADP+ | - |
? |  |
| D-glucose + NADPH + H+ | Homo sapiens | - |
sorbitol + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| aldose + NADPH + H+ | - |
Homo sapiens | alditol + NADP+ | - |
? | |
| D-glucose + NADPH + H+ | - |
Homo sapiens | sorbitol + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aldose reductase | - |
Homo sapiens |
| ALR2 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | dependent on | Homo sapiens | |
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Release 2023.1 (January 2023)
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