Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.21 extracted from

  • Eisenmann, M.; Steuber, H.; Zentgraf, M.; Altenkaemper, M.; Ortmann, R.; Perruchon, J.; Klebe, G.; Schlitzer, M.
    Structure-based optimization of aldose reductase inhibitors originating from virtual screening (2009), ChemMedChem, 4, 809-819.
    View publication on PubMed
Search for more literature for 1.1.1.21

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with the inhibitor IDD 594, hanging drop vapour diffusion method, using 40% (w/v) PEG 6000 in 50 mM diammonium hydrogen citrate at pH 5 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(E)-3-(5-(3-nitrophenyl)furan-2-yl)acrylic acid
-
 Homo sapiens
3-(2-phenylthiazole-4-yl)propanoic acid
-
 Homo sapiens
3-(5-(3-(trifluormethyl)phenyl)thiophene-2-yl)propanoic acid
-
 Homo sapiens
3-(5-(3-acetylphenyl)furan-2-yl)propanoic acid
-
 Homo sapiens
3-(5-(3-aminophenyl)furan-2-yl)propanoic acid
-
 Homo sapiens
3-(5-(3-methoxyphenyl)furan-2-yl)propanoic acid
-
 Homo sapiens
3-(5-(3-methoxyphenyl)thiophene-2-yl)propanoic acid
-
 Homo sapiens
3-(5-(3-methylphenyl)furan-2-yl)propanoic acid
-
 Homo sapiens
3-(5-(3-methylphenyl)thiophene-2-yl)propanoic acid
-
 Homo sapiens
3-(5-(3-methylsulfonyl)phenylfuran-2-yl)propanoic acid
-
 Homo sapiens
3-(5-(3-nitrophenyl)furan-2-yl)propanoic acid
-
 Homo sapiens
3-(5-(3-nitrophenyl)thiophene-2-yl)propanoic acid
-
 Homo sapiens
3-(5-(3-trifluormethyl)phenylfuran-2-yl)propanoic acid
-
 Homo sapiens
3-(5-phenylfuran-2-yl)propanoic acid
-
 Homo sapiens
3-(5-phenylthiophene-2-yl)propanoic acid
-
 Homo sapiens
3-(5-pyridine-2-yl-furan-2-yl)propanoic acid
-
 Homo sapiens
3-(5-pyridine-3-yl-furan-2-yl)propanoic acid
-
 Homo sapiens
4-(5-(3-methylphenyl)thiophene-2-yl)butanoic acid
-
 Homo sapiens
4-(5-phenylthiophene-2-yl)butanoic acid
-
 Homo sapiens
4-oxo-4-(5-(3-methylphenyl)thiophene-2-yl)butanoic acid
-
 Homo sapiens
4-oxo-4-(5-phenylthiophen-2-yl)butanoic acid
-
 Homo sapiens
IDD 594
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P15121
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose + NADPH + H+
-
 Homo sapiens sorbitol + NADP+
-
 ?
D-xylose + NADPH + H+
-
 Homo sapiens xylitol + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
aldose reductase
-
 Homo sapiens
ALR2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00017
-
 in sodium phosphate buffer (100 mM, pH 6.2) Homo sapiens 3-(5-(3-nitrophenyl)thiophene-2-yl)propanoic acid
0.00026
-
 in sodium phosphate buffer (100 mM, pH 6.2) Homo sapiens 3-(5-(3-nitrophenyl)furan-2-yl)propanoic acid
0.0019
-
 in sodium phosphate buffer (100 mM, pH 6.2) Homo sapiens 3-(5-(3-(trifluormethyl)phenyl)thiophene-2-yl)propanoic acid
0.002
-
 in sodium phosphate buffer (100 mM, pH 6.2) Homo sapiens 3-(5-(3-trifluormethyl)phenylfuran-2-yl)propanoic acid
0.003
-
 in sodium phosphate buffer (100 mM, pH 6.2) Homo sapiens 3-(5-(3-acetylphenyl)furan-2-yl)propanoic acid
0.0031
-
 in sodium phosphate buffer (100 mM, pH 6.2) Homo sapiens 4-(5-(3-methylphenyl)thiophene-2-yl)butanoic acid
0.004
-
 in sodium phosphate buffer (100 mM, pH 6.2) Homo sapiens 3-(5-(3-methylsulfonyl)phenylfuran-2-yl)propanoic acid
0.0041
-
 in sodium phosphate buffer (100 mM, pH 6.2) Homo sapiens 4-oxo-4-(5-(3-methylphenyl)thiophene-2-yl)butanoic acid
0.0049
-
 in sodium phosphate buffer (100 mM, pH 6.2) Homo sapiens 3-(5-(3-methylphenyl)thiophene-2-yl)propanoic acid
0.0053
-
 in sodium phosphate buffer (100 mM, pH 6.2) Homo sapiens 3-(5-phenylthiophene-2-yl)propanoic acid
0.0054
-
 in sodium phosphate buffer (100 mM, pH 6.2) Homo sapiens 3-(5-(3-methoxyphenyl)thiophene-2-yl)propanoic acid
0.0057
-
 in sodium phosphate buffer (100 mM, pH 6.2) Homo sapiens 3-(5-(3-methylphenyl)furan-2-yl)propanoic acid
0.0064
-
 in sodium phosphate buffer (100 mM, pH 6.2) Homo sapiens 4-(5-phenylthiophene-2-yl)butanoic acid
0.0065
-
 in sodium phosphate buffer (100 mM, pH 6.2) Homo sapiens 4-oxo-4-(5-phenylthiophen-2-yl)butanoic acid
0.0068
-
 in sodium phosphate buffer (100 mM, pH 6.2) Homo sapiens 3-(5-(3-methoxyphenyl)furan-2-yl)propanoic acid
0.014
-
 in sodium phosphate buffer (100 mM, pH 6.2) Homo sapiens 3-(5-(3-(trifluormethyl)phenyl)thiophene-2-yl)propanoic acid
0.016
-
 in sodium phosphate buffer (100 mM, pH 6.2) Homo sapiens 3-(5-phenylfuran-2-yl)propanoic acid
0.016
-
 in sodium phosphate buffer (100 mM, pH 6.2) Homo sapiens 3-(5-(3-aminophenyl)furan-2-yl)propanoic acid
0.019
-
 in sodium phosphate buffer (100 mM, pH 6.2) Homo sapiens (E)-3-(5-(3-nitrophenyl)furan-2-yl)acrylic acid
0.019
-
 in sodium phosphate buffer (100 mM, pH 6.2) Homo sapiens 3-(5-pyridine-3-yl-furan-2-yl)propanoic acid
0.022
-
 in sodium phosphate buffer (100 mM, pH 6.2) Homo sapiens 3-(2-phenylthiazole-4-yl)propanoic acid
0.031
-
 in sodium phosphate buffer (100 mM, pH 6.2) Homo sapiens 3-(5-pyridine-2-yl-furan-2-yl)propanoic acid