Crystallization (Comment) | Organism |
---|---|
in complex with the inhibitor IDD 594, hanging drop vapour diffusion method, using 40% (w/v) PEG 6000 in 50 mM diammonium hydrogen citrate at pH 5 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(E)-3-(5-(3-nitrophenyl)furan-2-yl)acrylic acid | - |
Homo sapiens | |
3-(2-phenylthiazole-4-yl)propanoic acid | - |
Homo sapiens | |
3-(5-(3-(trifluormethyl)phenyl)thiophene-2-yl)propanoic acid | - |
Homo sapiens | |
3-(5-(3-acetylphenyl)furan-2-yl)propanoic acid | - |
Homo sapiens | |
3-(5-(3-aminophenyl)furan-2-yl)propanoic acid | - |
Homo sapiens | |
3-(5-(3-methoxyphenyl)furan-2-yl)propanoic acid | - |
Homo sapiens | |
3-(5-(3-methoxyphenyl)thiophene-2-yl)propanoic acid | - |
Homo sapiens | |
3-(5-(3-methylphenyl)furan-2-yl)propanoic acid | - |
Homo sapiens | |
3-(5-(3-methylphenyl)thiophene-2-yl)propanoic acid | - |
Homo sapiens | |
3-(5-(3-methylsulfonyl)phenylfuran-2-yl)propanoic acid | - |
Homo sapiens | |
3-(5-(3-nitrophenyl)furan-2-yl)propanoic acid | - |
Homo sapiens | |
3-(5-(3-nitrophenyl)thiophene-2-yl)propanoic acid | - |
Homo sapiens | |
3-(5-(3-trifluormethyl)phenylfuran-2-yl)propanoic acid | - |
Homo sapiens | |
3-(5-phenylfuran-2-yl)propanoic acid | - |
Homo sapiens | |
3-(5-phenylthiophene-2-yl)propanoic acid | - |
Homo sapiens | |
3-(5-pyridine-2-yl-furan-2-yl)propanoic acid | - |
Homo sapiens | |
3-(5-pyridine-3-yl-furan-2-yl)propanoic acid | - |
Homo sapiens | |
4-(5-(3-methylphenyl)thiophene-2-yl)butanoic acid | - |
Homo sapiens | |
4-(5-phenylthiophene-2-yl)butanoic acid | - |
Homo sapiens | |
4-oxo-4-(5-(3-methylphenyl)thiophene-2-yl)butanoic acid | - |
Homo sapiens | |
4-oxo-4-(5-phenylthiophen-2-yl)butanoic acid | - |
Homo sapiens | |
IDD 594 | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P15121 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose + NADPH + H+ | - |
Homo sapiens | sorbitol + NADP+ | - |
? | |
D-xylose + NADPH + H+ | - |
Homo sapiens | xylitol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aldose reductase | - |
Homo sapiens |
ALR2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00017 | - |
in sodium phosphate buffer (100 mM, pH 6.2) | Homo sapiens | 3-(5-(3-nitrophenyl)thiophene-2-yl)propanoic acid | |
0.00026 | - |
in sodium phosphate buffer (100 mM, pH 6.2) | Homo sapiens | 3-(5-(3-nitrophenyl)furan-2-yl)propanoic acid | |
0.0019 | - |
in sodium phosphate buffer (100 mM, pH 6.2) | Homo sapiens | 3-(5-(3-(trifluormethyl)phenyl)thiophene-2-yl)propanoic acid | |
0.002 | - |
in sodium phosphate buffer (100 mM, pH 6.2) | Homo sapiens | 3-(5-(3-trifluormethyl)phenylfuran-2-yl)propanoic acid | |
0.003 | - |
in sodium phosphate buffer (100 mM, pH 6.2) | Homo sapiens | 3-(5-(3-acetylphenyl)furan-2-yl)propanoic acid | |
0.0031 | - |
in sodium phosphate buffer (100 mM, pH 6.2) | Homo sapiens | 4-(5-(3-methylphenyl)thiophene-2-yl)butanoic acid | |
0.004 | - |
in sodium phosphate buffer (100 mM, pH 6.2) | Homo sapiens | 3-(5-(3-methylsulfonyl)phenylfuran-2-yl)propanoic acid | |
0.0041 | - |
in sodium phosphate buffer (100 mM, pH 6.2) | Homo sapiens | 4-oxo-4-(5-(3-methylphenyl)thiophene-2-yl)butanoic acid | |
0.0049 | - |
in sodium phosphate buffer (100 mM, pH 6.2) | Homo sapiens | 3-(5-(3-methylphenyl)thiophene-2-yl)propanoic acid | |
0.0053 | - |
in sodium phosphate buffer (100 mM, pH 6.2) | Homo sapiens | 3-(5-phenylthiophene-2-yl)propanoic acid | |
0.0054 | - |
in sodium phosphate buffer (100 mM, pH 6.2) | Homo sapiens | 3-(5-(3-methoxyphenyl)thiophene-2-yl)propanoic acid | |
0.0057 | - |
in sodium phosphate buffer (100 mM, pH 6.2) | Homo sapiens | 3-(5-(3-methylphenyl)furan-2-yl)propanoic acid | |
0.0064 | - |
in sodium phosphate buffer (100 mM, pH 6.2) | Homo sapiens | 4-(5-phenylthiophene-2-yl)butanoic acid | |
0.0065 | - |
in sodium phosphate buffer (100 mM, pH 6.2) | Homo sapiens | 4-oxo-4-(5-phenylthiophen-2-yl)butanoic acid | |
0.0068 | - |
in sodium phosphate buffer (100 mM, pH 6.2) | Homo sapiens | 3-(5-(3-methoxyphenyl)furan-2-yl)propanoic acid | |
0.014 | - |
in sodium phosphate buffer (100 mM, pH 6.2) | Homo sapiens | 3-(5-(3-(trifluormethyl)phenyl)thiophene-2-yl)propanoic acid | |
0.016 | - |
in sodium phosphate buffer (100 mM, pH 6.2) | Homo sapiens | 3-(5-phenylfuran-2-yl)propanoic acid | |
0.016 | - |
in sodium phosphate buffer (100 mM, pH 6.2) | Homo sapiens | 3-(5-(3-aminophenyl)furan-2-yl)propanoic acid | |
0.019 | - |
in sodium phosphate buffer (100 mM, pH 6.2) | Homo sapiens | (E)-3-(5-(3-nitrophenyl)furan-2-yl)acrylic acid | |
0.019 | - |
in sodium phosphate buffer (100 mM, pH 6.2) | Homo sapiens | 3-(5-pyridine-3-yl-furan-2-yl)propanoic acid | |
0.022 | - |
in sodium phosphate buffer (100 mM, pH 6.2) | Homo sapiens | 3-(2-phenylthiazole-4-yl)propanoic acid | |
0.031 | - |
in sodium phosphate buffer (100 mM, pH 6.2) | Homo sapiens | 3-(5-pyridine-2-yl-furan-2-yl)propanoic acid |